Phenotypes associated with this allele

• Allele Symbol: Slc38a2^em1Zhxy
• Allele Name: endonuclease-mediated mutation 1, Xiaoyan Zhang
• Allele ID: MGI:7581890
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc38a2^em1Zhxy/Slc38a2^em1Zhxy	129.B6-Slc38a2^em1Zhxy	MGI:7581907

Genotype
MGI:7581907

hm1

• Allelic Composition: Slc38a2^em1Zhxy/Slc38a2^em1Zhxy
• Genetic Background: 129.B6-Slc38a2^em1Zhxy

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased ferroptosis ( J:345023 )

♂ • increased iron-dependent lipid peroxidation in the renal medulla of water-deprived male mice

♂ • water deprivation results in a marked increase in cell death in the renal medulla

renal/urinary system

increased urine osmolality ( J:345023 )

♂ • increased urine osmolyte excretion

♂ • after 24h water restriction no difference in urine osmolality is seen compared to wild-type controls

abnormal kidney morphology ( J:345023 )

♂ • increased malondialdehyde level in the renal medulla of water-deprived male mice

♂ • much higher levels of 4-Hydroxynonenal and 8-oxodG in the renal medulla of water-deprived male mice

♂ • more severe suppression of GPX4 levels and mTORC1 activity under water deprivation in male mice

increased kidney iron level ( J:345023 )

♂ • in the renal medulla of water deprived male mice

polyuria ( J:345023 )

♂ • increased urine volume to body weight ratio

homeostasis/metabolism

decreased kidney glutathione level ( J:345023 )

♂ • in the renal medulla of water deprived male mice

decreased superoxide dismutase level ( J:345023 )

♂ • in the renal medulla of water deprived male mice

increased kidney iron level ( J:345023 )

♂ • in the renal medulla of water deprived male mice

increased urine osmolality ( J:345023 )

♂ • increased urine osmolyte excretion

♂ • after 24h water restriction no difference in urine osmolality is seen compared to wild-type controls