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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Yap1tm1.2Hmc
targeted mutation 1.2, Helen McNeill
MGI:7581996
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Wwtr1tm1.2Hmc/Wwtr1tm1.2Hmc
Yap1tm1.2Hmc/Yap1+
Tg(Myh11-cre,-EGFP)2Mik/0 		involves: 129 * C57BL/6 * DBA/2 MGI:7861681


Genotype
MGI:7861681
cn1
Allelic
Composition		 Wwtr1tm1.2Hmc/Wwtr1tm1.2Hmc
Yap1tm1.2Hmc/Yap1+
Tg(Myh11-cre,-EGFP)2Mik/0
Genetic
Background		 involves: 129 * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh11-cre,-EGFP)2Mik mutation (1 available)
Wwtr1tm1.2Hmc mutation (2 available); any Wwtr1 mutation (26 available)
Yap1tm1.2Hmc mutation (1 available); any Yap1 mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal mitochondrial physiology ( J:344215 )
• aortic vascular smooth muscle (VSM) mitochondria show significantly lower maximal oxygen consumption and spare respiratory capacity, similar to what is observed in mice double homozygous for Wnt16tm2a(EUCOMM)Wtsi and Ldlrtm1Her




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory