All Phenotypes Ergic2<tm1.1Bcgen> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ergic2^tm1.1Bcgen/Ergic2^tm1.1Bcgen	Not Specified	MGI:7594026
cx2	Ergic2^tm1.1Bcgen/Ergic2^tm1.1Bcgen Ergic3^tm1.1Bcgen/Ergic3^tm1.1Bcgen	Not Specified	MGI:7594028

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal ventricle myocardium morphology ( J:345070 )

• Cx43 signal is reduced significantly in sections of ventricular myocardium; the number and size of Cx43 gap junction plaques in ventricular myocardium are significantly reduced

enlarged heart ( J:345070 )

• homozygous mice have larger hearts than wild-type littermates

• the ratio of heart weight to body weight (HW/BW) and heart weight to tibia length (HW/TL) is increased in 3 month old homozygous mice

increased heart ventricle size ( J:345070 )

• observed in homozygous mice at 3 months of age

increased heart left ventricle size ( J:345070 )

• both left ventricular internal dimension (LVID;s) and left ventricular volume (LV Vol;s) in systole were significantly increased in homozygous mice

decreased cardiac muscle contractility ( J:345070 )

• fractional shortening (FS) is decreased in homozygous mice

decreased heart ventricle muscle contractility ( J:345070 )

• ejection fraction (EF) is decreased in homozygous mice

muscle

abnormal ventricle myocardium morphology ( J:345070 )

• Cx43 signal is reduced significantly in sections of ventricular myocardium; the number and size of Cx43 gap junction plaques in ventricular myocardium are significantly reduced

decreased cardiac muscle contractility ( J:345070 )

• fractional shortening (FS) is decreased in homozygous mice

decreased heart ventricle muscle contractility ( J:345070 )

• ejection fraction (EF) is decreased in homozygous mice

growth/size/body

growth/size/body region phenotype ( J:345070 )

• homozygous mice do not display any obvious alteration in growth or appearance

enlarged heart ( J:345070 )

• homozygous mice have larger hearts than wild-type littermates

• the ratio of heart weight to body weight (HW/BW) and heart weight to tibia length (HW/TL) is increased in 3 month old homozygous mice

Allelic Composition	Ergic2^tm1.1Bcgen/Ergic2^tm1.1Bcgen Ergic3^tm1.1Bcgen/Ergic3^tm1.1Bcgen
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ergic2^tm1.1Bcgen mutation (0 available); any Ergic2 mutation (41 available)
Ergic3^tm1.1Bcgen mutation (0 available); any Ergic3 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

enlarged heart ( J:345070 )

• homozygous mice have larger hearts than wild-type littermates

• the ratio of heart weight to body weight (HW/BW) and heart weight to tibia length (HW/TL) is increased in 3 month old homozygous mice

increased heart ventricle size ( J:345070 )

• observed in homozygous mice at 3 months of age

growth/size/body

growth/size/body region phenotype ( J:345070 )

• homozygous mice do not display any obvious alteration in growth or appearance

enlarged heart ( J:345070 )

• homozygous mice have larger hearts than wild-type littermates

• the ratio of heart weight to body weight (HW/BW) and heart weight to tibia length (HW/TL) is increased in 3 month old homozygous mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24