About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ergic3tm1.1Bcgen
targeted mutation 1.1, Biocytogen
MGI:7582035
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ergic3tm1.1Bcgen/Ergic3tm1.1Bcgen Not Specified MGI:7594027
cx2
 		Ergic2tm1.1Bcgen/Ergic2tm1.1Bcgen
Ergic3tm1.1Bcgen/Ergic3tm1.1Bcgen 		Not Specified MGI:7594028


Genotype
MGI:7594027
hm1
Allelic
Composition		 Ergic3tm1.1Bcgen/Ergic3tm1.1Bcgen
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ergic3tm1.1Bcgen mutation (0 available); any Ergic3 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal ventricle myocardium morphology ( J:345070 )
• Cx43 signal is reduced significantly in sections of ventricular myocardium; the number and size of Cx43 gap junction plaques in ventricular myocardium are significantly reduced
enlarged heart ( J:345070 )
• homozygous mice have larger hearts than wild-type littermates
• the ratio of heart weight to body weight (HW/BW) and heart weight to tibia length (HW/TL) is increased in 3 month old homozygous mice
increased heart ventricle size ( J:345070 )
• observed in homozygous mice at 3 months of age
increased heart left ventricle size ( J:345070 )
• both left ventricular internal dimension (LVID;s) and left ventricular volume (LV Vol;s) in systole were significantly increased in homozygous mice
decreased cardiac muscle contractility ( J:345070 )
• fractional shortening (FS) is decreased in homozygous mice
decreased heart ventricle muscle contractility ( J:345070 )
• ejection fraction (EF) is decreased in homozygous mice

muscle
abnormal ventricle myocardium morphology ( J:345070 )
• Cx43 signal is reduced significantly in sections of ventricular myocardium; the number and size of Cx43 gap junction plaques in ventricular myocardium are significantly reduced
decreased cardiac muscle contractility ( J:345070 )
• fractional shortening (FS) is decreased in homozygous mice
decreased heart ventricle muscle contractility ( J:345070 )
• ejection fraction (EF) is decreased in homozygous mice

growth/size/body
growth/size/body region phenotype ( J:345070 )
N
• homozygous mice do not display any obvious alteration in growth or appearance
enlarged heart ( J:345070 )
• homozygous mice have larger hearts than wild-type littermates
• the ratio of heart weight to body weight (HW/BW) and heart weight to tibia length (HW/TL) is increased in 3 month old homozygous mice




Genotype
MGI:7594028
cx2
Allelic
Composition		 Ergic2tm1.1Bcgen/Ergic2tm1.1Bcgen
Ergic3tm1.1Bcgen/Ergic3tm1.1Bcgen
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ergic2tm1.1Bcgen mutation (0 available); any Ergic2 mutation (41 available)
Ergic3tm1.1Bcgen mutation (0 available); any Ergic3 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
enlarged heart ( J:345070 )
• homozygous mice have larger hearts than wild-type littermates
• the ratio of heart weight to body weight (HW/BW) and heart weight to tibia length (HW/TL) is increased in 3 month old homozygous mice
increased heart ventricle size ( J:345070 )
• observed in homozygous mice at 3 months of age

growth/size/body
growth/size/body region phenotype ( J:345070 )
• homozygous mice do not display any obvious alteration in growth or appearance
enlarged heart ( J:345070 )
• homozygous mice have larger hearts than wild-type littermates
• the ratio of heart weight to body weight (HW/BW) and heart weight to tibia length (HW/TL) is increased in 3 month old homozygous mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory