All Phenotypes Cfap52<em1Cya> MGI Mouse

hydrocephaly ( J:338033 )

• 52% of mice exhibit severe hydrocephalus

premature death ( J:338033 )

• the 52% of mice that exhibit severe hydrocephalus die within 2 months

abnormal sperm flagellum morphology ( J:338033 )

• midpiece and principal piece junction is disorganized

• about 19.66% of spermatozoa from the caudal epididymis shows thinning near the annulus that normally connects the midpiece with the principal piece of the flagellum compared to 3.77% of wild-type spermatozoa

• the midpiece and principal piece of the sperm tail are disconnected

• the thinning region is axoneme solely enveloped by outer dense fibers

• however, sperm flagellar axonemes show normal 9+ 2 microtubular organization and tail accessory structures

abnormal sperm mitochondrial sheath morphology ( J:338033 )

• the length of the mitochondrial sheath in spermatozoa is shorter

decreased sperm progressive motility ( J:338033 )

asthenozoospermia ( J:338033 )

• spermatozoa show low motility, with reduced path velocity, progressive velocity, and track speed

• however, males show normal spermatogenesis, with normal testis size and weight, normal seminiferous tubule structure and architecture, and normal sperm count

• dynein-driven microtubule sliding is disrupted in spermatozoa

male infertility ( J:338033 )

• males fail to produce offspring even though they show normal mounting behaviors and produce coital plugs

• however, females are fertile