Phenotypes associated with this allele

• Allele Symbol: Hspb6^em1Cya
• Allele Name: endonuclease-mediated mutation 1, Cyagen Biosciences
• Allele ID: MGI:7584374
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hspb6^em1Cya/Hspb6^em1Cya	C57BL/6J-Hspb6^em1Cya/Cya	MGI:7768078

Genotype
MGI:7768078

hm1

• Allelic Composition: Hspb6^em1Cya/Hspb6^em1Cya
• Genetic Background: C57BL/6J-Hspb6^em1Cya/Cya

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal aorta morphology ( J:347876 )

♂ • untreated mice show a significant increase in the protein level of phosphorylated cofilin (P-cofilin) and the proportion of F-actin in whole aortic tissues relative to wild-type controls, with no changes in the protein levels of cofilin, 14-3-3 or alpha-smooth muscle actin (alpha-SMA)

♂ • after beta-aminopropionitrile monofumarate (BAPN)-induced thoracic aortic aneurysm and dissection (TAAD), both P-cofilin expression and the F-actin percentage are further increased to levels that are significantly higher than in BAPN-treated controls

increased susceptibility to induced aneurysm formation ( J:347876 )

♂ • when 4-wk-old mice are fed a chow diet containing BAPN (4 g/kg) for 28 days to induce aortic aneurysm and dissection, males show a significantly higher rate of ascending aortic rupture than BAPN-treated controls

♂ • however, no differences in elastic fiber fracture, degradation or proteoglycan accumulation are detected in the aorta between the two groups

increased susceptibility to aneurysm induced morbidity/mortality ( J:347876 )

♂ • after BAPN-induced TAAD, males show a significantly higher mortality rate than BAPN-treated controls at day 28 (81.25% vs 50%, respectively)

mortality/aging

increased susceptibility to aneurysm induced morbidity/mortality ( J:347876 )

♂ • after BAPN-induced TAAD, males show a significantly higher mortality rate than BAPN-treated controls at day 28 (81.25% vs 50%, respectively)

cellular

increased apoptosis ( J:347876 )

♂ • in the BAPN-induced TAAD model, relative BAX protein expression and the ratio of cleaved caspase-3 to total caspase-3 are significantly higher than in BAPN-treated controls, suggesting increased apoptosis in aortic tissue cells