Phenotypes associated with this allele

• Allele Symbol: Rnf144b^em1Cya
• Allele Name: endonuclease-mediated mutation 1, Cyagen Biosciences
• Allele ID: MGI:7586259
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rnf144b^em1Cya/Rnf144b^em1Cya	C57BL/6J-Rnf144b^em1Cya/Cya	MGI:7787085

Genotype
MGI:7787085

hm1

• Allelic Composition: Rnf144b^em1Cya/Rnf144b^em1Cya
• Genetic Background: C57BL/6J-Rnf144b^em1Cya/Cya

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased susceptibility to Riboviria infection ( J:357974 )

• MEFs show impaired vesicular stomatitis virus (VSV) replication

• however, herpes simplex virus (HSV) replication is unaffected in MEFs

decreased susceptibility to Picornaviridae infection ( J:357974 )

• mice intraperitoneally injected with encephalomyocarditis virus (EMCV) at a non-lethal dose show reduced EMCV replication in heart and brain tissues, increased mRNA expression levels of IFN-beta and the proinflammatory cytokines IL-6 and TNF-alpha in the brain, and elevated levels of IFN-beta in the serum

• mouse embryonic fibroblasts (MEFs), bone marrow-derived dendritic cells (BMDCs) and bone marrow-derived macrophages (BMDMs) show an inhibition of EMCV replication

decreased susceptibility to Picornaviridae infection induced morbidity/mortality ( J:357974 )

• mice intraperitoneally injected with a high tier of encephalomyocarditis virus (EMCV) show higher survival rate than wild-type mice

mortality/aging

decreased susceptibility to Picornaviridae infection induced morbidity/mortality ( J:357974 )

• mice intraperitoneally injected with a high tier of encephalomyocarditis virus (EMCV) show higher survival rate than wild-type mice