Phenotypes associated with this allele

• Allele Symbol: Slc35e1^em1Cya
• Allele Name: endonuclease-mediated mutation 1, Cyagen Biosciences
• Allele ID: MGI:7586620
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc35e1^em1Cya/Slc35e1^em1Cya	C57BL/6J-Slc35e1^em1Cya	MGI:7627373

Genotype
MGI:7627373

hm1

• Allelic Composition: Slc35e1^em1Cya/Slc35e1^em1Cya
• Genetic Background: C57BL/6J-Slc35e1^em1Cya

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:340684 )

homeostasis/metabolism

abnormal zinc level ( J:340684 )

• zinc ion concentrations are increased in epidermal cells of both non-imiquimod and imiquimod treated skin

decreased physiological sensitivity to xenobiotic ( J:340684 )

• mice show decreased susceptibility to imiquimod-induced psoriasis, showing alleviation of psoriasis-like skin lesions, deceased inflammatory cells (CD45+ cells, Langerhans cells, gamma delta T cells, macrophages, and neutrophils) in the epidermis and dermis, and lower expression of cytokines IL-17a and IL-17f

integument

decreased keratinocyte proliferation ( J:340684 )

• imiqimod-treated mice show decreased number of proliferating keratinocytes in induced skin lesions

abnormal skin condition ( J:340684 )

• mice show a less severe imiquimod-induced psoriasis-like phenotype, with decreased keratinocyte proliferation and increased zinc ion levels in the epidermis

cellular

decreased keratinocyte proliferation ( J:340684 )

• imiqimod-treated mice show decreased number of proliferating keratinocytes in induced skin lesions