All Phenotypes Tmem182<em1Cya> MGI Mouse

abnormal myoblast differentiation ( J:314094 )

• primary skeletal muscle myoblasts from the leg muscles show increased number of myotubes and increased myoblast fusion rate, as determined by the greater number of nuclei in each myotube, indicating increased myoblast differentiation

abnormal myoblast fusion ( J:314094 )

• primary skeletal muscle myoblasts from the leg muscles show increased myoblast fusion rate

abnormal myoblast migration ( J:314094 )

• migration of primary myoblasts is increased in a wound healing assay

increased quadriceps weight ( J:314094 )

increased gastrocnemius weight ( J:314094 )

increased tibialis anterior weight ( J:314094 )

increased skeletal muscle fiber size ( J:314094 )

• the mean cross-sectional area and diameter of individual myofibers are larger than in wild-type mice

• mice have a higher proportion of larger myofibers

increased skeletal muscle fiber diameter ( J:314094 )

increased skeletal muscle fiber number ( J:314094 )

• mice exhibit more total muscle fibers than wild-type mice

increased skeletal muscle mass ( J:314094 )

increased skeletal muscle weight ( J:314094 )

• gastrocnemius, tibialis anterior, and quadriceps muscle weights are increased

• the ratio of muscle to body weight is increased

enhanced skeletal muscle regeneration ( J:314094 )

• mice injected with cardiotoxin to induce muscle injury show accelerated muscle regeneration, with replacement of most of the inflammatory myofibers by newly formed myofibers at 11 and 15 days after cardiotoxin injection and complete muscle regeneration and repair at 19 days