Phenotypes associated with this allele

• Allele Symbol: Socs4^m1Nch
• Allele Name: mutation 1, Sandra E Nicholson
• Allele ID: MGI:7587716
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Socs4^m1Nch/Socs4^m1Nch	C.C3Fe-Socs4^m1Nch	MGI:7593757
hm2	Socs4^m1Nch/Socs4^m1Nch	C3H/He-Socs4^m1Nch	MGI:7593761
hm3	Socs4^m1Nch/Socs4^m1Nch	C6.C3Fe-Socs4^m1Nch	MGI:7593763

Genotype
MGI:7593757

hm1

• Allelic Composition: Socs4^m1Nch/Socs4^m1Nch
• Genetic Background: C.C3Fe-Socs4^m1Nch

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:241977 )

N • normal thymocyte development and composition of peripheral immune cells under steady-state conditions

N • normal TGFB and IL10 levels in lung after i.n. inoculation with 10<3> pfu of influenza strain X31

N • normal cytokine and chemokine production in lung and spleen 3 days after systemic administration of poly I:C

decreased T cell number ( J:241977 )

• fewer virus-specific T cells in bronchioalveolar lavage (BAL) sample 5 and 6 days after intranasal (i.n.) inoculation with 10<3> pfu of influenza strain H3N2 A/Hong Kong x31 (X31)

• normal virus-specific T cell number in BAL sample 7 days after i.n. inoculation with 10<3> pfu of influenza strain X31

• normal virus-specific T cell number in mediastinal lymph node (MLN) after i.n. inoculation with 10<3> pfu of influenza strain X31

increased T cell number ( J:241977 )

• in lung 3 days after intranasal (i.n.) inoculation with 10<3> pfu of influenza strain H3N2 A/Hong Kong x31 (X31)

• more virus-specific T cells in spleen 5 and 6 days after intranasal (i.n.) inoculation with 10<3> pfu of influenza strain H3N2 A/Hong Kong x31 (X31)

• normal in lung 2 days after i.n. inoculation with 10<3> pfu of influenza strain X31

• normal virus-specific T cell number in spleen 7 days after i.n. inoculation with 10<3> pfu of influenza strain X31

• normal virus-specific T cell number in mediastinal lymph node (MLN) after i.n. inoculation with 10<3> pfu of influenza strain X31

abnormal T cell activation ( J:241977 )

• higher percentage of CD62L and lower percentage of CD62L CD8<+> T cells in mediastinal lymph node (MLN) 5 days after intranasal (i.n.) inoculation with 10<3> pfu of influenza strain H3N2 A/Hong Kong x31 (X31)

• normal 7 days after i.n. inoculation with 10<3> pfu of influenza strain X31

abnormal chemokine secretion ( J:241977 )

• increased CXCL1, CXCL2 and CCL2 levels in lung 3 days after intranasal (i.n.) inoculation with 10<3> pfu of influenza strain H3N2 A/Hong Kong x31 (X31)

• normal in lung 5-7 days after i.n. inoculation with 10<3> pfu of influenza strain X31

increased interferon-gamma secretion ( J:241977 )

• in lung 3 days after intranasal (i.n.) inoculation with 10<3> pfu of influenza strain H3N2 A/Hong Kong x31 (X31)

• normal in lung 5-7 days after i.n. inoculation with 10<3> pfu of influenza strain X31

increased interleukin-1 secretion ( J:241977 )

• normal in lung 5-7 days after i.n. inoculation with 10<3> pfu of influenza strain X31

• in lung 3 days after intranasal (i.n.) inoculation with 10<3> pfu of influenza strain H3N2 A/Hong Kong x31 (X31)

increased interleukin-12b secretion ( J:241977 )

• normal in lung 5-7 days after i.n. inoculation with 10<3> pfu of influenza strain X31

• in lung 3 days after intranasal (i.n.) inoculation with 10<3> pfu of influenza strain H3N2 A/Hong Kong x31 (X31)

increased interleukin-13 secretion ( J:241977 )

• normal in lung 5-7 days after i.n. inoculation with 10<3> pfu of influenza strain X31

• in lung 3 days after intranasal (i.n.) inoculation with 10<3> pfu of influenza strain H3N2 A/Hong Kong x31 (X31)

increased interleukin-4 secretion ( J:241977 )

• normal in lung 5-7 days after i.n. inoculation with 10<3> pfu of influenza strain X31

• in lung 3 days after intranasal (i.n.) inoculation with 10<3> pfu of influenza strain H3N2 A/Hong Kong x31 (X31)

increased interleukin-5 secretion ( J:241977 )

• normal in lung 5-7 days after i.n. inoculation with 10<3> pfu of influenza strain X31

• in lung 3 days after intranasal (i.n.) inoculation with 10<3> pfu of influenza strain H3N2 A/Hong Kong x31 (X31)

increased interleukin-6 secretion ( J:241977 )

• normal in lung 5-7 days after i.n. inoculation with 10<3> pfu of influenza strain X31

• in lung 3 days after intranasal (i.n.) inoculation with 10<3> pfu of influenza strain H3N2 A/Hong Kong x31 (X31)

increased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:241977 )

• increased lung viral load, disease progression (weight loss) and mortality after intranasal (i.n.) inoculation with 20 pfu of H1N1 influenza strain A/Puerto Rico/8/34 (PR8)

• increased lung viral load, disease progression (weight loss) and mortality after intranasal (i.n.) inoculation with 10<3> pfu of influenza strain H3N2 A/Hong Kong x31 (X31)

hematopoietic system

decreased T cell number ( J:241977 )

• fewer virus-specific T cells in bronchioalveolar lavage (BAL) sample 5 and 6 days after intranasal (i.n.) inoculation with 10<3> pfu of influenza strain H3N2 A/Hong Kong x31 (X31)

• normal virus-specific T cell number in BAL sample 7 days after i.n. inoculation with 10<3> pfu of influenza strain X31

• normal virus-specific T cell number in mediastinal lymph node (MLN) after i.n. inoculation with 10<3> pfu of influenza strain X31

increased T cell number ( J:241977 )

• in lung 3 days after intranasal (i.n.) inoculation with 10<3> pfu of influenza strain H3N2 A/Hong Kong x31 (X31)

• more virus-specific T cells in spleen 5 and 6 days after intranasal (i.n.) inoculation with 10<3> pfu of influenza strain H3N2 A/Hong Kong x31 (X31)

• normal in lung 2 days after i.n. inoculation with 10<3> pfu of influenza strain X31

• normal virus-specific T cell number in spleen 7 days after i.n. inoculation with 10<3> pfu of influenza strain X31

• normal virus-specific T cell number in mediastinal lymph node (MLN) after i.n. inoculation with 10<3> pfu of influenza strain X31

abnormal T cell activation ( J:241977 )

• higher percentage of CD62L and lower percentage of CD62L CD8<+> T cells in mediastinal lymph node (MLN) 5 days after intranasal (i.n.) inoculation with 10<3> pfu of influenza strain H3N2 A/Hong Kong x31 (X31)

• normal 7 days after i.n. inoculation with 10<3> pfu of influenza strain X31

growth/size/body

growth/size/body region phenotype ( J:241977 )

N • no obvious phenotype

embryo

embryo phenotype ( J:241977 )

N • viable

mortality/aging

increased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:241977 )

• increased lung viral load, disease progression (weight loss) and mortality after intranasal (i.n.) inoculation with 20 pfu of H1N1 influenza strain A/Puerto Rico/8/34 (PR8)

• increased lung viral load, disease progression (weight loss) and mortality after intranasal (i.n.) inoculation with 10<3> pfu of influenza strain H3N2 A/Hong Kong x31 (X31)

reproductive system

reproductive system phenotype ( J:241977 )

N • fertile

Genotype
MGI:7593761

hm2

• Allelic Composition: Socs4^m1Nch/Socs4^m1Nch
• Genetic Background: C3H/He-Socs4^m1Nch

immune system

immune system phenotype ( J:241977 )

N • normal thymocyte development and composition of peripheral immune cells under steady-state conditions

increased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:241977 )

• increased lung viral load, disease progression (weight loss) and mortality after intranasal (i.n.) inoculation with 10<3> pfu of influenza strain H3N2 A/Hong Kong x31 (X31)

growth/size/body

growth/size/body region phenotype ( J:241977 )

N • no obvious phenotype

embryo

embryo phenotype ( J:241977 )

N • viable

mortality/aging

increased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:241977 )

• increased lung viral load, disease progression (weight loss) and mortality after intranasal (i.n.) inoculation with 10<3> pfu of influenza strain H3N2 A/Hong Kong x31 (X31)

reproductive system

reproductive system phenotype ( J:241977 )

N • fertile

Genotype
MGI:7593763

hm3

• Allelic Composition: Socs4^m1Nch/Socs4^m1Nch
• Genetic Background: C6.C3Fe-Socs4^m1Nch

immune system

immune system phenotype ( J:241977 )

• normal thymocyte development and composition of peripheral immune cells under steady-state conditions

increased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:241977 )

• increased lung viral load, disease progression (weight loss) and mortality after intranasal (i.n.) inoculation with 10<3> pfu of influenza strain H3N2 A/Hong Kong x31 (X31)

growth/size/body

growth/size/body region phenotype ( J:241977 )

• no obvious phenotype

embryo

embryo phenotype ( J:241977 )

• viable

mortality/aging

increased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:241977 )

• increased lung viral load, disease progression (weight loss) and mortality after intranasal (i.n.) inoculation with 10<3> pfu of influenza strain H3N2 A/Hong Kong x31 (X31)

reproductive system

reproductive system phenotype ( J:241977 )

• fertile