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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Higd1cem1Chaa
endonuclease-mediated mutation 1, Andy J Chang
MGI:7587820
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Higd1cem1Chaa/Higd1cem1Chaa C57BL/6J-Higd1cem1Chaa MGI:7587834


Genotype
MGI:7587834
hm1
Allelic
Composition		 Higd1cem1Chaa/Higd1cem1Chaa
Genetic
Background		 C57BL/6J-Higd1cem1Chaa
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Higd1cem1Chaa mutation (0 available); any Higd1c mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
decreased pulmonary ventilation ( J:345095 )
• impaired hypoxic ventilatory response

homeostasis/metabolism
abnormal physiological response to hypoxia ( J:345095 )
• impaired hypoxic ventilatory response
• however, ventilatory responses to normoxia and hypercapnia are similar to controls

cardiovascular system
cardiovascular system phenotype ( J:345095 )
• number of TH-positive glomus cells in the carotid body is similar to wild-type controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory