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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lrrn1em2Dri
endonuclease-mediated mutation 2, Elizabeth Carroll Driver
MGI:7593846
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Lrrn1em2Dri/Lrrn1em2Dri involves: C57BL/6J MGI:7593855


Genotype
MGI:7593855
hm1
Allelic
Composition		 Lrrn1em2Dri/Lrrn1em2Dri
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrrn1em2Dri mutation (0 available); any Lrrn1 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
abnormal scala media morphology ( J:344891 )
• labeling of inner phalangeal cells and border cells indicates a shift in the sensory/nonsensory boundary in the cochlear duct
increased cochlear inner hair cell number ( J:344891 )
• increase in the number of IHC doublets along the length of the epithelium
• increase is seen in the basal, mid, and apical regions, but most pronounced in the apical region
• doublets of IHCs are detectable at E14

nervous system
increased cochlear inner hair cell number ( J:344891 )
• increase in the number of IHC doublets along the length of the epithelium
• increase is seen in the basal, mid, and apical regions, but most pronounced in the apical region
• doublets of IHCs are detectable at E14




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory