Phenotypes associated with this allele

• Allele Symbol: Otud6a^em1Smoc
• Allele Name: endonuclease-mediated mutation 1, Shanghai Model Organisms Center
• Allele ID: MGI:7594029
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Otud6a^em1Smoc/Otud6a^em1Smoc	C57BL/6J-Otud6a^em1Smoc	MGI:7594031

Genotype
MGI:7594031

hm1

• Allelic Composition: Otud6a^em1Smoc/Otud6a^em1Smoc
• Genetic Background: C57BL/6J-Otud6a^em1Smoc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal innate immunity ( J:345141 )

• enhanced innate immunity during viral infection in homozygous mice

decreased susceptibility to Herpesvirales infection ( J:345141 )

• increased resistance to lethal HSV-1 infection

• mice produced more type I interferon and stronger antiviral-related factors than controls

decreased susceptibility to Riboviria infection ( J:345141 )

• increased resistance to lethal VSV infection

• expression of antiviral-related factors was significantly higher in the blood than in controls