About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cabcoco1em1Gaof
endonuclease-mediated mutation 1, Fei Gao
MGI:7594038
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cabcoco1em1Gaof/Cabcoco1em1Gaof involves: 129/SvEv * C57BL/6 MGI:7596138


Genotype
MGI:7596138
hm1
Allelic
Composition		 Cabcoco1em1Gaof/Cabcoco1em1Gaof
Genetic
Background		 involves: 129/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cabcoco1em1Gaof mutation (0 available); any Cabcoco1 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
oligozoospermia ( J:345163 )
• sperm count is markedly decreased
teratozoospermia ( J:345163 )
• a large number of abnormal spermatozoa are noted in the epididymis
abnormal sperm flagellum morphology ( J:345163 )
• very few fiber-like AQP3 signals are detected in the epididymis and testes, and most of the AQP3 signal is dot-like
• percentage of caudal epididymal sperm with abnormal flagella is significantly increased; absent, short, and coiled sperm tails are observed
asthenozoospermia ( J:345163 )
• sperm motility is markedly reduced
abnormal spermiogenesis ( J:345163 )
• males exhibit abnormal sperm flagellogenesis
• however, no obvious histological defects are detected in the testes
male infertility ( J:345163 )
• males are sterile
• however, no obvious developmental defects are observed, and adult testis size and testis/body weight ratio are normal

cellular
oligozoospermia ( J:345163 )
• sperm count is markedly decreased
teratozoospermia ( J:345163 )
• a large number of abnormal spermatozoa are noted in the epididymis
abnormal sperm flagellum morphology ( J:345163 )
• very few fiber-like AQP3 signals are detected in the epididymis and testes, and most of the AQP3 signal is dot-like
• percentage of caudal epididymal sperm with abnormal flagella is significantly increased; absent, short, and coiled sperm tails are observed
asthenozoospermia ( J:345163 )
• sperm motility is markedly reduced




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory