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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cabcoco1em1Gaof
endonuclease-mediated mutation 1, Fei Gao
MGI:7594038
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cabcoco1em1Gaof/Cabcoco1em1Gaof involves: 129/SvEv * C57BL/6 MGI:7596138


Genotype
MGI:7596138
hm1
Allelic
Composition		 Cabcoco1em1Gaof/Cabcoco1em1Gaof
Genetic
Background		 involves: 129/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cabcoco1em1Gaof mutation (0 available); any Cabcoco1 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
oligozoospermia ( J:345163 )
• sperm count is markedly decreased
teratozoospermia ( J:345163 )
• a large number of abnormal spermatozoa are noted in the epididymis
abnormal sperm flagellum morphology ( J:345163 )
• very few fiber-like AQP3 signals are detected in the epididymis and testes, and most of the AQP3 signal is dot-like
• percentage of caudal epididymal sperm with abnormal flagella is significantly increased; absent, short, and coiled sperm tails are observed
asthenozoospermia ( J:345163 )
• sperm motility is markedly reduced
abnormal spermiogenesis ( J:345163 )
• males exhibit abnormal sperm flagellogenesis
• however, no obvious histological defects are detected in the testes
male infertility ( J:345163 )
• males are sterile
• however, no obvious developmental defects are observed, and adult testis size and testis/body weight ratio are normal

cellular
oligozoospermia ( J:345163 )
• sperm count is markedly decreased
teratozoospermia ( J:345163 )
• a large number of abnormal spermatozoa are noted in the epididymis
abnormal sperm flagellum morphology ( J:345163 )
• very few fiber-like AQP3 signals are detected in the epididymis and testes, and most of the AQP3 signal is dot-like
• percentage of caudal epididymal sperm with abnormal flagella is significantly increased; absent, short, and coiled sperm tails are observed
asthenozoospermia ( J:345163 )
• sperm motility is markedly reduced




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory