Phenotypes associated with this allele

• Allele Symbol: Rnf13^tm1.1Xgao
• Allele Name: targeted mutation 1.1, Xiang Gao
• Allele ID: MGI:7594042
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rnf13^tm1.1Xgao/Rnf13^tm1.1Xgao	B6.Cg-Rnf13^tm1.1Xgao	MGI:7705935

Genotype
MGI:7705935

hm1

• Allelic Composition: Rnf13^tm1.1Xgao/Rnf13^tm1.1Xgao
• Genetic Background: B6.Cg-Rnf13^tm1.1Xgao

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal spatial learning ( J:344668 )

• in the learning phase of the Morris water maze, mice show reduced efficiency in the execution of a standard learning task, showing decreased ability (increased escape latency) to reach the platform at days 2 and 3

• however, mice show normal memory retention in probe trials

impaired spatial working memory ( J:344668 )

• in the Y maze, mice show reduced alternation in exploratory behavior, indicating impaired working memory

increased anxiety-related response ( J:344668 )

• mice spend less time in the open arms of the elevated-plus maze, indicating anxiety

• however, the number of open arm entries in the elevated-plus maze does not differ from wild-type mice

• however, mice show no abnormalities in the open field, forced swimming test or tail suspension test

nervous system

abnormal synaptic bouton morphology ( J:344668 )

• synaptic vesicle density is decreased in the presynaptic bouton, while total vesicle number and the number of docked vesicle are unchanged

• however, the postsynaptic density, the synapse number, and cleft width are unchanged

abnormal excitatory synapse morphology ( J:344668 )

• mice exhibit structural alternation of synapses in the hippocampus, with abnormalities in the asymmetry of excitatory synapses of the hippocampal CA1 region

• increase in size of synaptic active zones