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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nudt15em1Maska
endonuclease-mediated mutation 1, Masahiro Kawahara
MGI:7595847
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nudt15em1Maska/Nudt15em1Maska C57BL/6-Nudt15em1Maska MGI:7596100
ht2
 		Nudt15em1Maska/Nudt15+ C57BL/6-Nudt15em1Maska MGI:7596101


Genotype
MGI:7596100
hm1
Allelic
Composition		 Nudt15em1Maska/Nudt15em1Maska
Genetic
Background		 C57BL/6-Nudt15em1Maska
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nudt15em1Maska mutation (0 available); any Nudt15 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:285800 )
• median lifespan of 21-26 days or 15-21 days after 1 or 2 mg/kg mercaptopurine (MP) administration, respectively
• minimum 70 day survival after 0.2 mg/kg mercaptopurine (MP) administration

hematopoietic system
decreased bone marrow cell number ( J:285800 )
• reduced number of nucleated BM cells after 5 days of 5 mg/kg mercaptopurine (MP) administration
decreased neutrophil cell number ( J:285800 )
• after 14 days of 1 or 7 or 14 days of 2 mg/kg mercaptopurine (MP) administration
• normal after 70 days of 0.2 mg/kg mercaptopurine (MP) administration
decreased hematopoietic stem cell number ( J:285800 )
• after 5 days of 2 or 5 mg/kg mercaptopurine (MP) administration
pancytopenia ( J:285800 )
• after 14 days of 1 or 2 mg/kg mercaptopurine (MP) administration
decreased hematopoietic precursor cell number ( J:285800 )
• reduced after 5 days of 2 mg/kg mercaptopurine (MP) administration

immune system
decreased neutrophil cell number ( J:285800 )
• after 14 days of 1 or 7 or 14 days of 2 mg/kg mercaptopurine (MP) administration
• normal after 70 days of 0.2 mg/kg mercaptopurine (MP) administration

growth/size/body
growth/size/body region phenotype ( J:285800 )
N
• normal esophagus, stomach, intestines, liver, lungs, and kidneys after 5 days of 5 mg/kg mercaptopurine (MP) administration

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
leukopenia DOID:615 J:285800
neutropenia DOID:1227 J:285800
pancytopenia DOID:12450 J:285800




Genotype
MGI:7596101
ht2
Allelic
Composition		 Nudt15em1Maska/Nudt15+
Genetic
Background		 C57BL/6-Nudt15em1Maska
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nudt15em1Maska mutation (0 available); any Nudt15 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased neutrophil cell number ( J:285800 )
• after 14 days of 1 or 2 mg/kg mercaptopurine (MP) administration
pancytopenia ( J:285800 )
• after 14 days of 1 or 2 mg/kg mercaptopurine (MP) administration

immune system
decreased neutrophil cell number ( J:285800 )
• after 14 days of 1 or 2 mg/kg mercaptopurine (MP) administration

mortality/aging
premature death ( J:285800 )
• median lifespan of 48-66 days or 30 days after 1 or 2 mg/kg mercaptopurine (MP) administration, respectively
• minimum 70 day survival after 0.2 mg/kg mercaptopurine (MP) administration

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
leukopenia DOID:615 J:285800
neutropenia DOID:1227 J:285800
pancytopenia DOID:12450 J:285800




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory