Phenotypes associated with this allele

• Allele Symbol: Tg(Myh6-Tmem11)#Kwan
• Allele Name: transgene insertion, Kun Wang
• Allele ID: MGI:7595946
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Myh6-Tmem11)#Kwan/0	C57BL/6JGpt-Tg(Myh6-Tmem11)#Kwan	MGI:7596058

Genotype
MGI:7596058

tg1

• Allelic Composition: Tg(Myh6-Tmem11)#Kwan/0
• Genetic Background: C57BL/6JGpt-Tg(Myh6-Tmem11)#Kwan

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased myocardial fiber size ( J:345326 )

• cardiomyocyte size is increased

• however, mice show normal cardiac morphology, heart-to-heart body ratio, hypertrophic marker expression, and cardiac function under physiological conditions

abnormal myocardial fiber physiology ( J:345326 )

• the number of proliferating cardiomyocytes is reduced in 7-day-old mice

increased susceptibility to myocardial ischemic injury ( J:345326 )

• 1-day-old mice subjected to myocardial infraction induced by coronary artery ligation show a decrease in cardiomyocyte proliferation, increased fibrotic area, and greater impairment of cardiac function, indicating hindered cardiac regeneration

homeostasis/metabolism

increased susceptibility to myocardial ischemic injury ( J:345326 )

• 1-day-old mice subjected to myocardial infraction induced by coronary artery ligation show a decrease in cardiomyocyte proliferation, increased fibrotic area, and greater impairment of cardiac function, indicating hindered cardiac regeneration

muscle

increased myocardial fiber size ( J:345326 )

• cardiomyocyte size is increased

• however, mice show normal cardiac morphology, heart-to-heart body ratio, hypertrophic marker expression, and cardiac function under physiological conditions