Analysis Tools
hearing/vestibular/ear
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• ABR wave I amplitudes from 5.6 kHz and upwards are reduced at high stimulus intensities (suprathreshold)
• however, ABR thresholds are unaltered across all sound frequencies tested, distortion product otoacoustic emissions (DPOAEs), even at sound intensities of 80-90 dB SPL, are unaffected in 2-month-old mice and, adolescent and adult mice exhibit normal nonlinear capacitance characteristics indicating a neuronal processing issue and not outer hair cell dysfunction
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nervous system
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• mice show a reduction in neurofilament labeled, nonmyelinated, afferent nerve fibers at the habenular in all three turns of the cochlea, as well as efferent nerve fibers, in the basal and middle turns of the cochlea
• however, no difference in the number of inner hair cell ribbon synapses in the basal, middle, and apical turn of the organ of Corti are seen
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