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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Slc25a44em1Kajim
endonuclease-mediated mutation 1, Shingo Kajimura
MGI:7596323
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Slc25a44em1Kajim/Slc25a44em1Kajim
Tg(Ucp1-cre)1Evdr/0
involves: C57BL/6 * FVB MGI:7596327


Genotype
MGI:7596327
cn1
Allelic
Composition
Slc25a44em1Kajim/Slc25a44em1Kajim
Tg(Ucp1-cre)1Evdr/0
Genetic
Background
involves: C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc25a44em1Kajim mutation (0 available); any Slc25a44 mutation (10 available)
Tg(Ucp1-cre)1Evdr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• mitochondrial valine oxidation is reduced by 70% in brown adipose tissue (BAT) indicating reduced branched amino acid oxidation

homeostasis/metabolism
• prostaglandin E2 (PGE2)-induced febrile response is substantially attenuated relative to controls, with lower total heat production and lower maximum temperature
• however, no difference in the velocity of the initial rise in iBAT temperature for the first 5 min after PGE2 administration is seen

growth/size/body
N
• mice exhibit normal body weight and tissue mass of metabolic organs, including brown adipose tissue, liver, white adipose tissue, and skeletal muscle on a regular chow diet and no differences in brown adipocytes are seen





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory