All Phenotypes Cxxc4<em1Mmda> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cxxc4^em1Mmda
endonuclease-mediated mutation 1, Meelad M Dawlaty
MGI:7606855

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cxxc4^em1Mmda/Cxxc4^em1Mmda	involves: 129S4/SvJae * C57BL/6	MGI:7606924
cx2	Cxxc4^em1Mmda/Cxxc4^em1Mmda Cxxc5^em1Mmda/Cxxc5^em1Mmda	involves: 129S4/SvJae * C57BL/6	MGI:7606926

Allelic Composition	Cxxc4^em1Mmda/Cxxc4^em1Mmda
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxxc4^em1Mmda mutation (0 available); any Cxxc4 mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal placenta junctional zone morphology ( J:344836 )

• subtle, but significant, expansion of junctional zone in placenta

abnormal placenta labyrinth size ( J:344836 )

• subtle, but significant, reduction of labyrinth layer in placenta

• however, placenta contains all layers

reproductive system

reproductive system phenotype ( J:344836 )

Allelic Composition	Cxxc4^em1Mmda/Cxxc4^em1Mmda Cxxc5^em1Mmda/Cxxc5^em1Mmda
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxxc4^em1Mmda mutation (0 available); any Cxxc4 mutation (13 available)
Cxxc5^em1Mmda mutation (0 available); any Cxxc5 mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal placenta morphology ( J:344836 )

• expression of trophoblast giant cell markers Pl1 and Plf are upregulated in placentas

• however, other trophectoderm markers are unchanged