Phenotypes associated with this allele

• Allele Symbol: Zfp503^tm1.1Lif
• Allele Name: targeted mutation 1.1, Fu-Chin Liu
• Allele ID: MGI:7606867
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zfp503^tm1.1Lif/Zfp503^tm1.1Lif	involves: 129 * C57BL/6	MGI:7606882

Genotype
MGI:7606882

hm1

• Allelic Composition: Zfp503^tm1.1Lif/Zfp503^tm1.1Lif
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:286635 )

• die immediately after birth

nervous system

abnormal neuronal migration ( J:286635 )

• abnormal migration of striatal cells from the dorsal to the ventral striatum

abnormal striatum morphology ( J:286635 )

• significant reductions in markers of striatonigral neurons at E18.5

• reduction of striatonigral axons along the projection pathway from the diencephalon and telencephalic boundaries through the cerebral peduncles to the substantia nigra

• however, proliferation and apotosis in the striatum analage and striatum are similar to controls

• abnormal redistribution of cells from the dorsal to the ventral striatum

abnormal dorsal striatum morphology ( J:286635 )

• smaller at E18.5

• Er81+ cells are present in prominent clusters in wild-type mice but are decreased in number and scattered in the dorsal striatum in null mice

• abnormalities are detected at E13.5

abnormal ventral striatum morphology ( J:286635 )

• larger at E18.5

• increase in the number of Er81+ cells

abnormal olfactory tubercle morphology ( J:286635 )

• Er81+ cells are present in prominent clusters in wild-type mice but are scattered in the dorsal striatum in null mice

cellular

abnormal neuronal migration ( J:286635 )

• abnormal migration of striatal cells from the dorsal to the ventral striatum