Phenotypes associated with this allele

• Allele Symbol: Orm2^em1Bcgen
• Allele Name: endonuclease-mediated mutation 1, Biocytogen LLC
• Allele ID: MGI:7607189
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Orm2^em1Bcgen/Orm2^em1Bcgen	involves: C57BL/6J	MGI:7607204
ht2	Orm2^em1Bcgen/Orm2^+	involves: C57BL/6J	MGI:7607206

Genotype
MGI:7607204

hm1

• Allelic Composition: Orm2^em1Bcgen/Orm2^em1Bcgen
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

liver inflammation ( J:333118 )

• increased expression of hepatic inflammatory genes on a high fat diet

• increased abundance of F4/80-positive macrophages

adipose tissue

adipose tissue phenotype ( J:333118 )

N • no difference in body weight, leptin concentrations, inguinal white adipose tissue, and brown adipose tissue on a high fat diet compared to diet matched controls

growth/size/body

increased liver weight ( J:333118 )

• increase in liver to body weight ratio when on a normal chow diet

• also on a high cholesterol and high fructose in male mice compared to diet matched controls

homeostasis/metabolism

increased circulating LDL cholesterol level ( J:333118 )

• on a high fat diet

increased circulating triglyceride level ( J:333118 )

• increased plasma levels when on a normal chow diet

• on a high cholesterol and high fructose diet in males

increased circulating alanine transaminase level ( J:333118 )

• on a high fat diet

• on a high cholesterol and high fructose diet in males

increased circulating aspartate transaminase level ( J:333118 )

• on a high fat diet

• on a high cholesterol and high fructose diet in males

increased liver triglyceride level ( J:333118 )

• when on a normal chow diet

• on a high cholesterol and high fructose diet in males

liver/biliary system

increased liver weight ( J:333118 )

• increase in liver to body weight ratio when on a normal chow diet

• also on a high cholesterol and high fructose in male mice compared to diet matched controls

increased liver triglyceride level ( J:333118 )

• when on a normal chow diet

• on a high cholesterol and high fructose diet in males

liver inflammation ( J:333118 )

• increased expression of hepatic inflammatory genes on a high fat diet

• increased abundance of F4/80-positive macrophages

hepatic steatosis ( J:333118 )

• develop more aggravated hepatic steatosis on a high fat diet compared to diet matched controls

• males develop more aggravated hepatic steatosis on high cholesterol and high fructose compared to diet matched controls

liver fibrosis ( J:333118 )

Genotype
MGI:7607206

ht2

• Allelic Composition: Orm2^em1Bcgen/Orm2⁺
• Genetic Background: involves: C57BL/6J

liver/biliary system

increased liver triglyceride level ( J:333118 )

♂ • on a high cholesterol and high fructose diet in males

homeostasis/metabolism

increased circulating triglyceride level ( J:333118 )

♂ • on a high cholesterol and high fructose diet in males

increased circulating alanine transaminase level ( J:333118 )

♂ • on a high cholesterol and high fructose diet in males

increased liver triglyceride level ( J:333118 )

♂ • on a high cholesterol and high fructose diet in males