mortality/aging
N |
• mice show similar survival as single Tg(Thy1-MAPT*P301S)58.2Npa hemizygotes or single Lamp5em1Lmit homozygotes
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behavior/neurological
• mice show impaired learning in the Morris water maze compared to single Tg(Thy1-MAPT*P301S)58.2Npa hemizygotes
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• mice show impaired memory in the Morris water maze compared to single Tg(Thy1-MAPT*P301S)58.2Npa hemizygotes
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nervous system
• EEG recording shows increased numbers of spontaneous discharges and elevated high frequency spectral power while frequency of spectral power (theta) is reduced and theta/gamma cross frequency coupling, an EEG measure linked to memory, is compromised compared to single Tg(Thy1-MAPT*P301S)58.2Npa hemizyotes
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