Phenotypes associated with this allele

• Allele Symbol: Lhx5as1^em1Jzx
• Allele Name: endonuclease-mediated mutation 1, Jianzhong Xi
• Allele ID: MGI:7608119
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lhx5as1^em1Jzx/Lhx5as1^em1Jzx	C57BL/6J-Lhx5as1^em1Jzx	MGI:7610037

Genotype
MGI:7610037

hm1

• Allelic Composition: Lhx5as1^em1Jzx/Lhx5as1^em1Jzx
• Genetic Background: C57BL/6J-Lhx5as1^em1Jzx

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased excitatory postsynaptic current amplitude ( J:328356 )

• decreased AMPAR evoked EPSCs amplitudes in the hippocampal CA3-CA1 pathway

• suppressed NMDAR-EPSCs amplitudes

• ratio of NMDAR/AMPAR=EPSC at ~300 pA is significantly reduced

reduced long-term potentiation ( J:328356 )

• significantly attenuated but still present in the hippocampus

decreased miniature excitatory postsynaptic current amplitude ( J:328356 )

• slight decrease in amplitude but no change in frequency in hippocampal CA1 pyramidal neurons in culture

behavior/neurological

impaired spatial learning ( J:328356 )

• spend less time in the target zone, take longer to reach the zone and cover more distance to reach the target zone on test days in a Morris water maze

• in a Barnes maze have difficulty in finding the target hole during training and test phases

abnormal spatial working memory ( J:328356 )

• on training days take longer to find the platform in a Morris water maze

• in a Barnes maze have difficulty in finding the target hole during training and test phases