All Phenotypes Pja2<tm1.2Afel> MGI Mouse

• body weight is reduced at P30 but this difference in weight disappears by P60

abnormal kidney vasculature morphology ( J:345592 )

• kidneys show dilated ectatic vessels in both the cortical and medullary regions, altering the normal renal architecture

• dilations contain a very slender and flattened endothelium and are associated with interstitial edema expanding the connective tissue framework evenly separating the tubules

abnormal glomerular capillary morphology ( J:345592 )

• shrinkage and hypocellularity of the capillary tufts

increased mesangial cell number ( J:345592 )

• the one mouse with cortical atrophy shows slight mesangial hyperplasia

kidney inflammation ( J:345592 )

• the edematous fibrovascular stroma is focally and moderately infiltrated by chronic inflammatory cells such as lymphocytes and plasma cells

increased glomerular capsule space ( J:345592 )

• Bowmans space is widened

abnormal mesangial matrix morphology ( J:345592 )

• PAS+ material in the mesangial matrix

renal glomerulus atrophy ( J:345592 )

• renal glomeruli appear diffusely and moderately atrophic with a slight multifocal and PAS+ material in the mesangial matrix, widened Bowmans space, and shrinkage and hypocellularity of the capillary tufts

kidney cortex atrophy ( J:345592 )

• one mouse shows focal and severe cortical atrophy

hydronephrosis ( J:345592 )

• moderate hydronephrosis is seen in one mouse

dilated renal tubule ( J:345592 )

• renal tubular ectasia with some cases showing pyknotic nuclei indicative of necroptosis