Phenotypes associated with this allele

• Allele Symbol: Ttc39aos1^tm1Kaf
• Allele Name: targeted mutation 1, Katherine A Fitzgerald
• Allele ID: MGI:7610578
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ttc39aos1^tm1Kaf/Ttc39aos1^tm1Kaf	C57BL/6-Ttc39aos1^tm1Kaf	MGI:7610580

Genotype
MGI:7610580

hm1

• Allelic Composition: Ttc39aos1^tm1Kaf/Ttc39aos1^tm1Kaf
• Genetic Background: C57BL/6-Ttc39aos1^tm1Kaf

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to endotoxin shock ( J:234649 )

• mice challenged with LPS to induce endotoxic shock exhibit elevated levels of inflammatory cytokines in serum, peritoneal fluid, liver, and spleen, and protein levels of immune genes including Cxcl10, Ccl5, and IL6 are elevated both locally in peritoneal fluid and systemically in serum, spleen, and liver, however recruitment of immune cells, including neutrophils and inflammatory monocytes is similar to wild-type mice

• at sub-lethal dose of LPS challenge, mice show higher susceptibility to endotoxic shock, with 100% of mice succumbing to death by 30 hours compared to 50% of wild-type mice

• at low non-lethal dose of LPS, mice show increased susceptibility to endotoxic shock, with only 20% of mice surviving up to to 5 days post-LPS challenge compared to 100% survival for wild-type mice

• however, mice under normal conditions are healthy and show no gross developmental defects, and exhibit normal numbers of macrophages, dendritic cells, B cells, T cells, and natural killer cells in spleens

hematopoietic system

hematopoietic system phenotype ( J:234649 )

N • mice exhibit normal erythropoiesis including hematocrit and hemogolobin levels and red blood cell numbers, and normal numbers of macrophages and dendritic cells