Phenotypes associated with this allele

• Allele Symbol: Gpcpd1^{tm1c(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:7610680
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gpcpd1^tm1c(EUCOMM)Hmgu/Gpcpd1^tm1c(EUCOMM)Hmgu Speer6-ps1^Tg(Alb-cre)21Mgn/Speer6-ps1^+	involves: C57BL/6 * DBA	MGI:7610684
cn2	Gpcpd1^tm1c(EUCOMM)Hmgu/Gpcpd1^tm1c(EUCOMM)Hmgu Tg(Fabp4-cre)1Rev/0	involves: C57BL/6J * C57BL/6N	MGI:7610685
cn3	Gpcpd1^tm1c(EUCOMM)Hmgu/Gpcpd1^tm1c(EUCOMM)Hmgu Tg(Ckmm-cre)5Khn/0	involves: C57BL/6J * C57BL/6N * FVB	MGI:7610682
cn4	Gpcpd1^tm1c(EUCOMM)Hmgu/Gpcpd1^tm1c(EUCOMM)Hmgu Tg(Ucp1-cre)1Evdr/0	involves: C57BL/6J * C57BL/6N * FVB	MGI:7610686

Genotype
MGI:7610684

cn1

• Allelic Composition: Gpcpd1^{tm1c(EUCOMM)Hmgu}/Gpcpd1^{tm1c(EUCOMM)Hmgu}; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: involves: C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:345630 )

♂N • do not show glucose intolerance at 12 weeks of age

Genotype
MGI:7610685

cn2

• Allelic Composition: Gpcpd1^{tm1c(EUCOMM)Hmgu}/Gpcpd1^{tm1c(EUCOMM)Hmgu}; Tg(Fabp4-cre)1Rev/0
• Genetic Background: involves: C57BL/6J * C57BL/6N

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:345630 )

♂ • do not show glucose intolerance at 12 weeks of age

Genotype
MGI:7610682

cn3

• Allelic Composition: Gpcpd1^{tm1c(EUCOMM)Hmgu}/Gpcpd1^{tm1c(EUCOMM)Hmgu}; Tg(Ckmm-cre)5Khn/0
• Genetic Background: involves: C57BL/6J * C57BL/6N * FVB

muscle

muscle phenotype ( J:345630 )

♂N • normal muscle development, morphology, and size at 6 and 20 months of age

♂N • distribution of fiber type, myofiber size, muscle and mitochondrial ultrastructure, and muscle strength are similar to controls at 20 months of age

increased muscle cell glucose uptake ( J:345630 )

♂ • increased uptake in skeletal and cardiac muscle at 12 weeks of age

♂ • no change in glucose uptake in white fat, subcutaneous fat, brown fat, or liver

increased cardiac muscle cell glucose uptake ( J:345630 )

♂ • at 12 weeks of age

abnormal muscle glycogen level ( J:345630 )

♂ • decreased muscle glycogen levels at 20 months of age

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:345630 )

♂N • blood insulin levels are similar to controls

increased insulin secretion ( J:345630 )

♂ • increased insulin release at 12 weeks of age

hyperglycemia ( J:345630 )

♂ • fed and fasting hyperglycemia at 20 months of age but not at 12 weeks of age

impaired glucose tolerance ( J:345630 )

♂ • severe glucose intolerance at 12 weeks and 20 months of age

♂ • severe defect in glucose clearance after 10 weeks on a high-sugar diet or high fat diet that is worse than in diet matched controls

♂ • however, no difference in weight gain is seen in mice on a high sugar or high fat diet compared to diet matched controls

abnormal muscle glycogen level ( J:345630 )

♂ • decreased muscle glycogen levels at 20 months of age

increased glycerophosphocholine level ( J:345630 )

• in muscle, resulting in an increase in muscle osmolarity in 24 month old mice

endocrine/exocrine glands

increased insulin secretion ( J:345630 )

♂ • increased insulin release at 12 weeks of age

cardiovascular system

increased cardiac muscle cell glucose uptake ( J:345630 )

♂ • at 12 weeks of age

cellular

increased muscle cell glucose uptake ( J:345630 )

♂ • increased uptake in skeletal and cardiac muscle at 12 weeks of age

♂ • no change in glucose uptake in white fat, subcutaneous fat, brown fat, or liver

increased cardiac muscle cell glucose uptake ( J:345630 )

♂ • at 12 weeks of age

Genotype
MGI:7610686

cn4

• Allelic Composition: Gpcpd1^{tm1c(EUCOMM)Hmgu}/Gpcpd1^{tm1c(EUCOMM)Hmgu}; Tg(Ucp1-cre)1Evdr/0
• Genetic Background: involves: C57BL/6J * C57BL/6N * FVB

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:345630 )

♂ • do not show glucose intolerance at 12 weeks of age