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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tor1aip1tm1.1Wtd
targeted mutation 1.1, William T Dauer
MGI:7610707
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Tor1atm3.1Wtd/Tor1atm3.1Wtd
Tor1aip1tm1.1Wtd/Tor1aip1tm1.1Wtd
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA MGI:7611647
cn2
 		Tor1atm3.1Wtd/Tor1atm3.1Wtd
Tor1aip1tm1.1Wtd/Tor1aip1+
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA MGI:7611650
cn3
 		Tor1atm3.1Wtd/Tor1a+
Tor1aip1tm1.1Wtd/Tor1aip1tm1.1Wtd
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA MGI:7611653
cn4
 		Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Tor1aip1tm1.1Wtd/Tor1aip1tm1.1Wtd 		Not Specified MGI:7611657


Genotype
MGI:7611647
cn1
Allelic
Composition		 Tor1atm3.1Wtd/Tor1atm3.1Wtd
Tor1aip1tm1.1Wtd/Tor1aip1tm1.1Wtd
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
Tor1aip1tm1.1Wtd mutation (0 available); any Tor1aip1 mutation (42 available)
Tor1atm3.1Wtd mutation (1 available); any Tor1a mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
abnormal hepatocyte morphology ( J:345574 )
• decrease in the number of nuclei containing 2 or more lipid droplets compared to mutant mice wild-type for Tor1a, 7 +/- 3% compared to 64 +/- 5%
hepatic steatosis ( J:345574 )
• grossly white livers
abnormal liver physiology ( J:345574 )
• decreased triglyceride, apoB100, and apoB48 secretion rates




Genotype
MGI:7611650
cn2
Allelic
Composition		 Tor1atm3.1Wtd/Tor1atm3.1Wtd
Tor1aip1tm1.1Wtd/Tor1aip1+
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
Tor1aip1tm1.1Wtd mutation (0 available); any Tor1aip1 mutation (42 available)
Tor1atm3.1Wtd mutation (1 available); any Tor1a mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
hepatic steatosis ( J:345574 )
• grossly white livers




Genotype
MGI:7611653
cn3
Allelic
Composition		 Tor1atm3.1Wtd/Tor1a+
Tor1aip1tm1.1Wtd/Tor1aip1tm1.1Wtd
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
Tor1aip1tm1.1Wtd mutation (0 available); any Tor1aip1 mutation (42 available)
Tor1atm3.1Wtd mutation (1 available); any Tor1a mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
abnormal hepatocyte morphology ( J:345574 )
• decrease in the number of nuclei containing 2 or more lipid droplets compared to mutant mice wild-type for Tor1a, 33 +/- 7% compared to 64 +/- 5%
hepatic steatosis ( J:345574 )
• grossly white livers




Genotype
MGI:7611657
cn4
Allelic
Composition		 Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Tor1aip1tm1.1Wtd/Tor1aip1tm1.1Wtd
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
Tor1aip1tm1.1Wtd mutation (0 available); any Tor1aip1 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
abnormal hepatocyte morphology ( J:345574 )
• most (64 +/- 5%) nuclei contain 2 or more lipid droplets




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/09/2024
MGI 6.24 		The Jackson Laboratory