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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Phf5atm1.1Oux
targeted mutation 1.1, Xijun Ou
MGI:7611699
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cd79atm1(cre)Reth/Cd79a+
Phf5atm1.1Oux/Phf5atm1.1Oux
Tg(IghelMD4)4Ccg/0 		involves: BALB/c * C57BL/6 * C57BL/6J MGI:7611733
cn2
 		Cd79atm1(cre)Reth/Cd79a+
Phf5atm1.1Oux/Phf5atm1.1Oux 		involves: BALB/c * C57BL/6J MGI:7611716


Genotype
MGI:7611733
cn1
Allelic
Composition		 Cd79atm1(cre)Reth/Cd79a+
Phf5atm1.1Oux/Phf5atm1.1Oux
Tg(IghelMD4)4Ccg/0
Genetic
Background		 involves: BALB/c * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Phf5atm1.1Oux mutation (0 available); any Phf5a mutation (19 available)
Tg(IghelMD4)4Ccg mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal B cell number ( J:345807 )
• addition of a pre-rearranged IgH transgene partially but significantly increases the number of CD19+ B cells

immune system
abnormal B cell number ( J:345807 )
• addition of a pre-rearranged IgH transgene partially but significantly increases the number of CD19+ B cells




Genotype
MGI:7611716
cn2
Allelic
Composition		 Cd79atm1(cre)Reth/Cd79a+
Phf5atm1.1Oux/Phf5atm1.1Oux
Genetic
Background		 involves: BALB/c * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Phf5atm1.1Oux mutation (0 available); any Phf5a mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal B cell receptor editing ( J:345807 )
• defect in RAG-mediated recombination
abnormal immunoglobulin heavy chain V(D)J recombination ( J:345807 )
• significant reduction in the diversity of IgH chain repetoires
decreased early pro-B cell number ( J:345807 )
• decreased absolute numbers of BP1- CD24+ early pro-B cells
decreased late pro-B cell number ( J:345807 )
• decreased absolute numbers of BP1+ CD24high late pro-B cells
increased pre-pro B cell number ( J:345807 )
• increase in frequency and absolute number of BP1- CD24- pre-pro-B cells
• no increase in proliferation of pre-pro-B cells
decreased B cell number ( J:345807 )
• approximately sixfold decrease in both percentage and total number of B220+ B cells in the bone marrow
• percentages and absolute numbers of B220+ CD43- late-stage B cells and B220high CD43- recirculating B cells are decreased
• severe B lymphopenia in the periphery
decreased immature B cell number ( J:345807 )
• drastically reduced B220+ CD43+ IgM+ IgD- immature B cell numbers
decreased mature B cell number ( J:345807 )
• dramatic reduction in the number of B220+ splenic B cells
• IgD+ mature B cells are virtually absent in the spleen
decreased pre-B cell number ( J:345807 )
• drastically reduced B220+ CD43- IgM- IgD- small pre-B cell numbers
abnormal B cell physiology ( J:345807 )
• defect in IgH chain gene expression in pre-pro-B cells

immune system
abnormal B cell receptor editing ( J:345807 )
• defect in RAG-mediated recombination
abnormal immunoglobulin heavy chain V(D)J recombination ( J:345807 )
• significant reduction in the diversity of IgH chain repetoires
decreased early pro-B cell number ( J:345807 )
• decreased absolute numbers of BP1- CD24+ early pro-B cells
decreased late pro-B cell number ( J:345807 )
• decreased absolute numbers of BP1+ CD24high late pro-B cells
increased pre-pro B cell number ( J:345807 )
• no increase in proliferation of pre-pro-B cells
• increase in frequency and absolute number of BP1- CD24- pre-pro-B cells
decreased B cell number ( J:345807 )
• approximately sixfold decrease in both percentage and total number of B220+ B cells in the bone marrow
• percentages and absolute numbers of B220+ CD43- late-stage B cells and B220high CD43- recirculating B cells are decreased
• severe B lymphopenia in the periphery
decreased immature B cell number ( J:345807 )
• drastically reduced B220+ CD43+ IgM+ IgD- immature B cell numbers
decreased mature B cell number ( J:345807 )
• dramatic reduction in the number of B220+ splenic B cells
• IgD+ mature B cells are virtually absent in the spleen
decreased pre-B cell number ( J:345807 )
• drastically reduced B220+ CD43- IgM- IgD- small pre-B cell numbers
abnormal B cell physiology ( J:345807 )
• defect in IgH chain gene expression in pre-pro-B cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory