Phenotypes associated with this allele

• Allele Symbol: Gne^em1Lx
• Allele Name: endonuclease-mediated mutation 1, Lijun Xia
• Allele ID: MGI:7611836
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gne^em1Lx/Gne^em1Lx	C57BL/6J-Gne^em1Lx	MGI:7611840
ht2	Gne^em1Lx/Gne^+	C57BL/6J-Gne^em1Lx	MGI:7611841

Genotype
MGI:7611840

hm1

• Allelic Composition: Gne^em1Lx/Gne^em1Lx
• Genetic Background: C57BL/6J-Gne^em1Lx

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:345585 )

N • normal vitelline vein and capillary plexus in yolk sac

abnormal perineural vascular plexus morphology ( J:345585 )

• fewer vascular sprouts in neural tissues extending from perineural vascular plexus in E11 embryos

• distended and dilated vascular sprouts in neural tissues extending from perineural vascular plexus in E11 and E11.5 embryos

intracranial hemorrhage ( J:345585 )

• bleeding into 3rd ventricle from diencephalon in E11.5 embryos

spinal hemorrhage ( J:345585 )

• in E11.5 embryos

mortality/aging

embryonic lethality prior to tooth bud stage, complete penetrance ( J:345585 )

• embryos die by E12.5 from hemorrhages

nervous system

intracranial hemorrhage ( J:345585 )

• bleeding into 3rd ventricle from diencephalon in E11.5 embryos

spinal hemorrhage ( J:345585 )

• in E11.5 embryos

Genotype
MGI:7611841

ht2

• Allelic Composition: Gne^em1Lx/Gne⁺
• Genetic Background: C57BL/6J-Gne^em1Lx

growth/size/body

growth/size/body region phenotype ( J:345585 )

N • normal development

mortality/aging

mortality/aging ( J:345585 )

N • normal lifespan