Phenotypes associated with this allele

• Allele Symbol: Arfip2^{tm1d(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1d, Wellcome Trust Sanger Institute
• Allele ID: MGI:7611851
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Arfip2^tm1d(EUCOMM)Wtsi/Arfip2^tm1d(EUCOMM)Wtsi	involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N * CBA	MGI:7611853

Genotype
MGI:7611853

hm1

• Allelic Composition: Arfip2^{tm1d(EUCOMM)Wtsi}/Arfip2^{tm1d(EUCOMM)Wtsi}
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:345639 )

N • mice do not show any developmental abnormalities or changes in kidney/body weight and exhibit no increase in proteinuria levels after 18 months

albuminuria ( J:345639 )

♂ • mice with STZ-induced type I diabetic nephropathy show increased albumin/creatinine ratio

abnormal podocyte foot process morphology ( J:345639 )

♂ • podocyte foot processes show an increase in widening and misconfiguration in mice with STZ-induced type I diabetic nephropathy compared to controls

abnormal podocyte slit diaphragm morphology ( J:345639 )

♂ • mice with STZ-induced type I diabetic nephropathy show decreased slit diaphragm density and slit diaphragms that are partially translocated to proximal parts of food processes compared to controls

homeostasis/metabolism

impaired autophagy ( J:345639 )

♂ • autophagy is impaired in mice with STZ-induced type I diabetic nephropathy

albuminuria ( J:345639 )

♂ • mice with STZ-induced type I diabetic nephropathy show increased albumin/creatinine ratio

increased physiological sensitivity to xenobiotic ( J:345639 )

♂ • mice intraperitoneally injected with streptozotocin (STZ) to induce type I diabetes develop increased albuminuria and mild nephropathy (glomerular hypertrophy, hyperfiltration) but no differences in kidney weight/body weight ratios, in blood glucose levels, or in glomerular sclerosis compared to controls

cellular

impaired autophagy ( J:345639 )

♂ • autophagy is impaired in mice with STZ-induced type I diabetic nephropathy