Analysis Tools
growth/size/body
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• tamoxifen-treated mice fed a high-fat diet gain less body weight than controls
• tamoxifen-treated mice injected with DEN exhibit a lower increase in body weight compared to DEN-injected controls, regardless of diet; this is due to reduced adiposity and not growth
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liver/biliary system
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• tamoxifen-treated mice are resistant to developing high-fat diet induced non-alcohol fatty liver disease
• tamoxifen-treated mice, injected with DEN and fed a high-fat diet show strongly reduced hepatic steatosis
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neoplasm
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• mice treated with tamoxifen on days 1 to 3 after birth then injected with diethylnitrosamine (DEN) 14 days later to induce hepatic carcinogenesis and fed a high-fat diet show a decrease in liver tumor number, average tumor size and maximum tumor size compared with controls, indicating decreased susceptibility to DEN-induced tumorigenesis on a high-fat diet
• tumor regions show increased hepatocyte apoptosis and a greater accumulation of macrophages than in controls
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• a greater accumulation of macrophages is seen in tumors from high-diet fed, DEN-injected, and tamoxifen-treated mutants than in controls
• tumor regions, but not non-tumor regions, from tamoxifen-treated, DEN-injected, and high-fat diet fed mice show increased hepatocyte apoptosis
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homeostasis/metabolism
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• tamoxifen-treated mice fed a high-fat diet gain less body weight than controls
• tamoxifen-treated mice injected with DEN exhibit a lower increase in body weight compared to DEN-injected controls, regardless of diet; this is due to reduced adiposity and not growth
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• tamoxifen-treated mice, injected with DEN and fed a low-fat diet show lower glycemia than controls
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• tamoxifen-treated mice fed a low-fat diet exhibit higher insulin levels
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• tamoxifen-treated mice fed a high-fat diet show a reduction in alanine aminotransferase (ALT) activity in plasma compared to controls, indicating reduced hepatocellular injury
• tamoxifen-treated mice, injected with DEN and fed a high-fat diet show blunted ALT activity
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• tamoxifen-treated mice fed a high-fat diet exhibit improved glucose tolerance
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• the HOMA-IR index is blunted in tamoxifen-treated mice fed a high-fat diet compared to an increase in controls
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• mice treated with tamoxifen on days 1 to 3 after birth then injected with diethylnitrosamine (DEN) 14 days later to induce hepatic carcinogenesis and fed a high-fat diet show a decrease in liver tumor number, average tumor size and maximum tumor size compared with controls, indicating decreased susceptibility to DEN-induced tumorigenesis on a high-fat diet
• tumor regions show increased hepatocyte apoptosis and a greater accumulation of macrophages than in controls
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behavior/neurological
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• tamoxifen-treated mice fed a high-fat diet have a higher food intake than controls
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adipose tissue
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• tamoxifen-treated mice injected with DEN show reduced adiposity, as seen by smaller adipose depots, regardless of diet
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