Phenotypes associated with this allele

• Allele Symbol: Hcar1^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Pharmaceuticals
• Allele ID: MGI:7612088
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hcar1^tm1Lex/Hcar1^tm1Lex	involves: C57BL/6J	MGI:7612097

Genotype
MGI:7612097

hm1

• Allelic Composition: Hcar1^tm1Lex/Hcar1^tm1Lex
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal retina vasculature morphology ( J:282266 )

• significant delay in intraretinal vascularization at P8 and P9 but is caught up to wild-type by P14

• however, superficial retinal vascular development is similar to wild-type

• treatment with lactate fails to accelerate inner retinal vascularization unlike in wild-type mice

abnormal retina ganglion cell morphology ( J:314286 )

• fewer ipsilateral projections from retinal ganglion cells are present in the dorsal lateral geniculate nucleus

abnormal eye physiology ( J:282266 )

• exposure to 75% O2 at P7 led to greater retinal vaso-obliteration compared to similarly treated wild-type controls

increased retina apoptosis ( J:282266 )

• significant numbers of apoptotic cells are detected at P11 in the inner nuclear layer

decreased b-wave amplitude ( J:282266 )

• decreased photopic and scotopic b-wave amplitudes at P30

• however, a-waves are hardly affected

abnormal cone electrophysiology ( J:282266 )

• reduced b-wave amplitudes

abnormal rod electrophysiology ( J:282266 )

• reduced b-wave amplitudes

reproductive system

abnormal uterus physiology ( J:345898 )

• treatment with lactate fails to attenuate expression of IL1B induced proinflammatory and prolabor genes unlike in wild-type mice

cardiovascular system

abnormal retina vasculature morphology ( J:282266 )

• significant delay in intraretinal vascularization at P8 and P9 but is caught up to wild-type by P14

• however, superficial retinal vascular development is similar to wild-type

• treatment with lactate fails to accelerate inner retinal vascularization unlike in wild-type mice

cellular

increased retina apoptosis ( J:282266 )

• significant numbers of apoptotic cells are detected at P11 in the inner nuclear layer

nervous system

abnormal lateral geniculate nucleus morphology ( J:282266 )

• fewer ipsilateral projections from retinal ganglion cells are present in the dorsal lateral geniculate nucleus

abnormal retina ganglion cell morphology ( J:314286 )

• fewer ipsilateral projections from retinal ganglion cells are present in the dorsal lateral geniculate nucleus