Phenotypes associated with this allele

• Allele Symbol: Mldhr^em1Zhgn
• Allele Name: endonuclease-mediated mutation 1, Nu Zhang
• Allele ID: MGI:7612218
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mldhr^em1Zhgn/Mldhr^em1Zhgn	involves: C57BL/6	MGI:7612224

Genotype
MGI:7612224

hm1

• Allelic Composition: Mldhr^em1Zhgn/Mldhr^em1Zhgn
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased cellular ATP level ( J:303725 )

• elevated in MEFs

abnormal cell physiology ( J:303725 )

• increased secreted lactate levels in MEFs

abnormal tricarboxylic acid cycle ( J:303725 )

• increased expression of many substrates of the TCA cycle in MEFs

adipose tissue

decreased body fat mass ( J:303725 )

• decreased fat weight

homeostasis/metabolism

increased cellular ATP level ( J:303725 )

• elevated in MEFs

increased circulating lactate level ( J:303725 )

• in serum

increased oxygen consumption ( J:303725 )

• in MEFs

abnormal glucose homeostasis ( J:303725 )

• elevated glucose consumption in MEFs and mice

growth/size/body

decreased body fat mass ( J:303725 )

• decreased fat weight