Phenotypes associated with this allele

• Allele Symbol: Etfdh^{tm1c(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:7612287
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Etfdh^tm1c(EUCOMM)Hmgu/Etfdh^tm1c(EUCOMM)Hmgu Tg(ACTA1-rtTA,tetO-cre)102Monk/0	involves: C3H * C57BL/6 * C57BL/6N	MGI:7614304

Genotype
MGI:7614304

cn1

• Allelic Composition: Etfdh^{tm1c(EUCOMM)Hmgu}/Etfdh^{tm1c(EUCOMM)Hmgu}; Tg(ACTA1-rtTA,tetO-cre)102Monk/0
• Genetic Background: involves: C3H * C57BL/6 * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired coordination ( J:345923 )

• 6-month-old doxycycline-treated mice show decreased performance on the rotarod test and the two-limb hanging test in response to fasting, but not in the fed state

cellular

abnormal skeletal muscle fiber mitochondrial morphology ( J:345923 )

• some skeletal muscle mitochondria from doxycycline-treated mice appear swollen, empty and with cristae disorganization

abnormal oxidative phosphorylation ( J:345923 )

• isolated mitochondria from skeletal muscle shows reduced oxidative phosphorylation complex III (CIII) activity

• cytochrome c production in isolated mitochondria is reduced to 54% of wild-type

growth/size/body

decreased body weight ( J:345923 )

• doxycycline-treated mice exhibit reduced body weight by 5-6 months of age

weight loss ( J:345923 )

• 5-month-old doxycycline-treated mice show a poorer response to fasting, showing greater weight loss after fasting than controls

muscle

abnormal skeletal muscle fiber mitochondrial morphology ( J:345923 )

• some skeletal muscle mitochondria from doxycycline-treated mice appear swollen, empty and with cristae disorganization

abnormal muscle physiology ( J:345923 )

• mice show increased skeletal muscle de novo lipid synthesis in close contact with dysfunctional mitochondria

myopathy ( J:345923 )

• skeletal muscle from doxycycline-treated mice shows fiber shrinkage, sarcomere disorganization and debris, indicating myopathy