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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hoxb3osem1Kabo
endonuclease-mediated mutation 1, Karam Aoudehen
MGI:7612311
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hoxb3osem1Kabo/Hoxb3osem1Kabo C57BL/6J-Hoxb3osem1Kabo MGI:7612600
cn2
 		Hoxb3osem1Kabo/Hoxb3osem1Kabo
Pkd1tm2Ggg/Pkd1tm2Ggg
Tg(Pkhd1-cre)1Igr/0 		involves: 129S4/SvJae * C57BL/6J MGI:7612601
cx3
 		Hoxb3osem1Kabo/Hoxb3osem1Kabo
Pkd1tm1.1Pcha/Pkd1tm1.1Pcha 		involves: 129 * C57BL/6J MGI:7612602


Genotype
MGI:7612600
hm1
Allelic
Composition		 Hoxb3osem1Kabo/Hoxb3osem1Kabo
Genetic
Background		 C57BL/6J-Hoxb3osem1Kabo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxb3osem1Kabo mutation (0 available); any Hoxb3os mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased kidney cell proliferation ( J:345935 )
• cell proliferation in P10 kidney is increased

mortality/aging
mortality/aging ( J:345935 )
N
• mice live an average life span

renal/urinary system
renal/urinary system phenotype ( J:345935 )
N
• mice exhibit a normal kidney morphology in the cortex and medulla, normal serum creatinine and BUN levels, and normal kidney tubule morphology
increased kidney cell proliferation ( J:345935 )
• cell proliferation in P10 kidney is increased




Genotype
MGI:7612601
cn2
Allelic
Composition		 Hoxb3osem1Kabo/Hoxb3osem1Kabo
Pkd1tm2Ggg/Pkd1tm2Ggg
Tg(Pkhd1-cre)1Igr/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxb3osem1Kabo mutation (0 available); any Hoxb3os mutation (3 available)
Pkd1tm2Ggg mutation (1 available); any Pkd1 mutation (154 available)
Tg(Pkhd1-cre)1Igr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
increased kidney cell proliferation ( J:345935 )
• percentage of Ki67+ cells is increased by 52% in kidneys, indicating increased cell proliferation
kidney cyst ( J:345935 )
• mice exhibit exacerbated cyst growth in kidneys compared to single Pdk1 homozygotes, with a 64% increase in cyst index, 52% increase in cyst number, and 74% increase in kidney weight/body weight ratio

cellular
increased kidney cell proliferation ( J:345935 )
• percentage of Ki67+ cells is increased by 52% in kidneys, indicating increased cell proliferation

growth/size/body
kidney cyst ( J:345935 )
• mice exhibit exacerbated cyst growth in kidneys compared to single Pdk1 homozygotes, with a 64% increase in cyst index, 52% increase in cyst number, and 74% increase in kidney weight/body weight ratio




Genotype
MGI:7612602
cx3
Allelic
Composition		 Hoxb3osem1Kabo/Hoxb3osem1Kabo
Pkd1tm1.1Pcha/Pkd1tm1.1Pcha
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxb3osem1Kabo mutation (0 available); any Hoxb3os mutation (3 available)
Pkd1tm1.1Pcha mutation (0 available); any Pkd1 mutation (154 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
increased kidney cell proliferation ( J:345935 )
• percentage of Ki67+ cells is increased by 60% in kidneys, indicating increased cell proliferation
kidney cyst ( J:345935 )
• mice exhibit exacerbated cyst growth in kidneys compared to single Pdk1 homozygotes, with a 71% increase in cyst index, 64% increase in cyst number, and 27% increase in kidney weight/body weight ratio

cellular
increased kidney cell proliferation ( J:345935 )
• percentage of Ki67+ cells is increased by 60% in kidneys, indicating increased cell proliferation

growth/size/body
kidney cyst ( J:345935 )
• mice exhibit exacerbated cyst growth in kidneys compared to single Pdk1 homozygotes, with a 71% increase in cyst index, 64% increase in cyst number, and 27% increase in kidney weight/body weight ratio




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory