Phenotypes associated with this allele

• Allele Symbol: Cand1^em1Zpan
• Allele Name: endonuclease-mediated mutation 1, Zhenwei Pan
• Allele ID: MGI:7614261
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cand1^em1Zpan/Cand1^em1Zpan	C57BL/6J-Cand1^em1Zpan	MGI:7614265
ht2	Cand1^em1Zpan/Cand1^+	C57BL/6J-Cand1^em1Zpan	MGI:7614266

Genotype
MGI:7614265

hm1

• Allelic Composition: Cand1^em1Zpan/Cand1^em1Zpan
• Genetic Background: C57BL/6J-Cand1^em1Zpan

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:345515 )

• embryonic lethal

Genotype
MGI:7614266

ht2

• Allelic Composition: Cand1^em1Zpan/Cand1⁺
• Genetic Background: C57BL/6J-Cand1^em1Zpan

cardiovascular system

increased response of heart to induced stress ( J:345515 )

• mice exhibit exacerbated transverse aortic constriction (TAC)-induced cardiac hypertrophy and heart failure, showing severe left ventricular dysfunction, with decreases in left ventricular ejection fraction, fractional shortening, left ventricle internal dimension at end-diastole (LVIDs) and left ventricle internal dimension at systole (LVIDd) and higher death rate at 6 weeks post-TAC compared to wild-type controls

• hypertrophic phenotypes induced by TAC, including gross heart size, ratios of heart weight to body weight, heart weight to tibia length, and lung weight to body weight are exaggerated and magnitude of TAC-induced increases in cell size and cardiac fibrosis is greater than in wild-type controls

homeostasis/metabolism

increased response of heart to induced stress ( J:345515 )

• mice exhibit exacerbated transverse aortic constriction (TAC)-induced cardiac hypertrophy and heart failure, showing severe left ventricular dysfunction, with decreases in left ventricular ejection fraction, fractional shortening, left ventricle internal dimension at end-diastole (LVIDs) and left ventricle internal dimension at systole (LVIDd) and higher death rate at 6 weeks post-TAC compared to wild-type controls

• hypertrophic phenotypes induced by TAC, including gross heart size, ratios of heart weight to body weight, heart weight to tibia length, and lung weight to body weight are exaggerated and magnitude of TAC-induced increases in cell size and cardiac fibrosis is greater than in wild-type controls

abnormal susceptibility to injury induced morbidity/mortality ( J:345515 )

• death rate at 6 weeks post-TAC is higher than in wild-type mice (70% vs. 32%)

mortality/aging

abnormal susceptibility to injury induced morbidity/mortality ( J:345515 )

• death rate at 6 weeks post-TAC is higher than in wild-type mice (70% vs. 32%)