Phenotypes associated with this allele

• Allele Symbol: Cdca7^em1Ldax
• Allele Name: endonuclease-mediated mutation 1, Lucia Daxinger
• Allele ID: MGI:7614313
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Cdca7^em1Ldax/Cdca7^em1Ldax Tg(HBA1-GFP)1Ew/0	FVB/NJ-Cdca7^em1Ldax Tg(HBA1-GFP)1Ew	MGI:7614332

Genotype
MGI:7614332

cx1

• Allelic Composition: Cdca7^em1Ldax/Cdca7^em1Ldax; Tg(HBA1-GFP)1Ew/0
• Genetic Background: FVB/NJ-Cdca7^em1Ldax Tg(HBA1-GFP)1Ew

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal DNA methylation ( J:345314 )

• lower levels of chromatin-bound CDCA7 protein in E10.5 embryos

• higher percentage of erythrocytes expressing Tg(HBA1-GFP)1Ew transgene at age P21

• lower transgene Tg(HBA1-GFP)1Ew DNA methylation levels at age P21

• global DNA hypomethylation in spleen, thymus, cerebrum and liver at age P21

• DNA hypomethylation of minor satellite repeats and intracisternal A particle (IAP) retrotransposons in spleen, thymus and liver at age P21

• normal DNA methylation of major satellite repeats in spleen, thymus and liver at age P21

embryo

embryo phenotype ( J:345314 )

N • mice born at expected Mendelian ratios

growth/size/body

growth/size/body region phenotype ( J:345314 )

N • no obvious phenotype

mortality/aging

mortality/aging ( J:345314 )

N • viable

N • mice present at expected Mendelian ratios at age P21