Analysis Tools
behavior/neurological
| N |
• no deficits in open-field locomotion
|
|
• profound reduction in responses to cotton swab touches and paw-withdrawal responses to von Frey filaments
• however, responses to brush stimuli and heat withdrawal thresholds are similar to controls
|
nervous system
|
• 40% of AB fibers have no detectable mechanosensitive receptive field
• firing rates of slowly adapting mechanoreceptors show strongly reduced responses to static constant force phase of a stimulus at all stimulus strengths
• overall firing rates of rapidly adapting mechanorecptors are signigicantly reduced compared to controls
• however, there is no obvious loss of mechanoreceptor endings in the skin
• no change in the firing response of mechanosensitive C fibers
|
|
• reduction in the proportion of rapidly adapting mechanically activated currents in nociceptors
• small but significant elevation in the amplitude of indentation needed to evoke the first mechanically activated current in nociceptors
|
|
• in isolated large sensory neurons only half display any rapidly adapting mechanically activated currents
• large sensory neurons show a slightly depolarized resting membrane potentials
|
