Phenotypes associated with this allele

• Allele Symbol: Rnf126^tm1Bcgen
• Allele Name: targeted mutation 1, Biocytogen
• Allele ID: MGI:7614507
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rnf126^tm1Bcgen/Rnf126^tm1Bcgen	C57BL/6-Rnf126^tm1Bcgen	MGI:7705946

Genotype
MGI:7705946

cn1

• Allelic Composition: Rnf126^tm1Bcgen/Rnf126^tm1Bcgen
• Genetic Background: C57BL/6-Rnf126^tm1Bcgen

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal response to radiation ( J:344817 )

• when mice are treated with cre-PyMT expressing virus to induce breast tumors and then those tumors are transplanted in situ into the breasts of FVB/N mice, tumors lacking Rnf126 show a greater growth inhibition and reduction in volume and higher level of breast cancer cell apoptosis following low-dose radiotherapy than wild-type tumors, indicating increased efficacy of radiotherapy