Phenotypes associated with this allele

• Allele Symbol: Klk5^em1Mer
• Allele Name: endonuclease-mediated mutation 1, Marc E Rothenberg
• Allele ID: MGI:7614802
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Klk5^em1Mer/Klk5^em1Mer	BALB/c-Klk5^em1Mer	MGI:7614880

Genotype
MGI:7614880

hm1

• Allelic Composition: Klk5^em1Mer/Klk5^em1Mer
• Genetic Background: BALB/c-Klk5^em1Mer

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal gut flora balance ( J:344772 )

• the commensal microbiome in the esophagus is modified, with an increase in the portion of Proteobacteria and a decrease in Firmicutes, Bacteroidetes, and Cyanobacteria

• the abundance of Ruminococcaceae and Lachnospiraceae bacteria, which are increased in the intestine of patients with milk allergy, is decreased compared to wild-type mice

immune system

abnormal acute inflammation ( J:344772 )

• mice show impaired esophageal allergic inflammation; mice in which esophageal allergic inflammation was induced intranasally via chicken egg albumin (OVA) show increased expression of serum IgE comparable to wild-type controls, however the number of eosinophils in the esophagus is decreased 3-fold compared to wild-type controls

• OVA-treated mice do not show epithelial thickening as seen in wild-type controls

• OVA-treated mice have a 40% decrease in the percent of eosinophils in the blood compared to OVA-treated controls

• however, blood mast cell protease I (marker of mast cell load and degranulation) is comparable to wild-type