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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Alpk1em1Dlka
endonuclease-mediated mutation 1, Daniel L Kastner
MGI:7614851
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Alpk1em1Dlka/Alpk1+
Crb1rd8/Crb1+ 		involves: C57BL/6J * C57BL/6N MGI:7614876
cx2
 		Alpk1em1Dlka/Alpk1em1Dlka
Crb1rd8/Crb1rd8 		involves: C57BL/6N MGI:7614873


Genotype
MGI:7614876
cx1
Allelic
Composition		 Alpk1em1Dlka/Alpk1+
Crb1rd8/Crb1+
Genetic
Background		 involves: C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alpk1em1Dlka mutation (0 available); any Alpk1 mutation (78 available)
Crb1rd8 mutation (18 available); any Crb1 mutation (92 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
vision/eye phenotype ( J:344848 )
N
• normal fundus morphology and ERG amplitudes at age 9 and 12 months




Genotype
MGI:7614873
cx2
Allelic
Composition		 Alpk1em1Dlka/Alpk1em1Dlka
Crb1rd8/Crb1rd8
Genetic
Background		 involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alpk1em1Dlka mutation (0 available); any Alpk1 mutation (78 available)
Crb1rd8 mutation (18 available); any Crb1 mutation (92 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
growth/size/body region phenotype ( J:344848 )
N
• normal body and spleen weight at age 6, 12 and 16 weeks

homeostasis/metabolism
abnormal circulating chemokine level ( J:344848 )
• increased serum CXCL1 and CCL2 levels at age 2 and 3 months
increased circulating CXCL10 level ( J:344848 )
• increased serum CXCL10 levels at age 2 and 3 months

immune system
immune system phenotype ( J:344848 )
N
• normal spleen weight at age 6, 12 and 16 weeks
abnormal circulating chemokine level ( J:344848 )
• increased serum CXCL1 and CCL2 levels at age 2 and 3 months
increased circulating CXCL10 level ( J:344848 )
• increased serum CXCL10 levels at age 2 and 3 months




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory