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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mbtps2em1Sapo
endonuclease-mediated mutation 1, Sandra Pohl
MGI:7614892
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mbtps2em1Sapo/Mbtps2em1Sapo C57BL/6J-Mbtps2em1Sapo MGI:7615084
ht2
 		Mbtps2em1Sapo/Mbtps2+ C57BL/6J-Mbtps2em1Sapo MGI:7615086
ot3
 		Mbtps2em1Sapo/Y C57BL/6J-Mbtps2em1Sapo MGI:7615085


Genotype
MGI:7615084
hm1
Allelic
Composition		 Mbtps2em1Sapo/Mbtps2em1Sapo
Genetic
Background		 C57BL/6J-Mbtps2em1Sapo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mbtps2em1Sapo mutation (0 available); any Mbtps2 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality between implantation and somite formation ( J:344727 )
• no embryos found at E6.5, E8.5, E12.5 or E15.5




Genotype
MGI:7615086
ht2
Allelic
Composition		 Mbtps2em1Sapo/Mbtps2+
Genetic
Background		 C57BL/6J-Mbtps2em1Sapo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mbtps2em1Sapo mutation (0 available); any Mbtps2 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
skeleton phenotype ( J:344727 )
N
• normal growth plate length
• no osteoarthritic phenotype in articular cartilage of tibia at age 12 weeks
• normal bone mineralization heterogeneity in tibia at age 12 weeks
• normal osteocyte lacunar number and area in tibia at age 12 weeks
decreased subchondral bone mineral content ( J:344727 )
• in tibia at age 12 weeks
abnormal osteocyte canaliculus morphology ( J:344727 )
• fewer and shorter canaliculi in tibia at age 12 weeks
• smaller total lacunocanalicular area in tibia at age 12 weeks
abnormal trabecular bone morphology ( J:344727 )
• decreased mineralization in tibia at age 12 weeks
increased chondrocyte number ( J:344727 )
• increased number of chondrocyte clusters, with greater number of chondrocytes per cluster, in articular cartilage of tibia at age 12 weeks
abnormal articular cartilage morphology ( J:344727 )
• increased number of chondrocyte clusters, with greater number of chondrocytes per cluster, in articular cartilage of tibia at age 12 weeks
• thicker in tibia at age 12 weeks
• no osteoarthritic phenotype in articular cartilage of tibia at age 12 weeks
decreased bone mineralization ( J:344727 )
• hypomineralized subchondral and trabecular bone in tibia at age 12 weeks
• normal bone mineralization heterogeneity in tibia at age 12 weeks
• normal osteocyte lacunar number and area in tibia at age 12 weeks

growth/size/body
growth/size/body region phenotype ( J:344727 )
N
• normal size




Genotype
MGI:7615085
ot3
Allelic
Composition		 Mbtps2em1Sapo/Y
Genetic
Background		 C57BL/6J-Mbtps2em1Sapo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mbtps2em1Sapo mutation (0 available); any Mbtps2 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality between implantation and somite formation ( J:344727 )
• no embryos found at E6.5, E8.5, E12.5 or E15.5




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory