Analysis Tools
homeostasis/metabolism
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• male mice fed a high-fat/high-sucrose diet for 8 weeks and subjected to left anterior descending (LAD) coronary artery ligation with 45-min ischemia followed by reperfusion show a 28% improvement in left ventricular (LV) ejection fraction (EF) and a 23% improvement in fractional shortening (FS) relative to control mice, as assessed by short-axis M-mode echocardiography at 2 days post I/R injury
• at 2 days post myocardial infarction, male mice also show a smaller change in EF and FS relative to baseline measurements and a 32% improvement of the LV EF by long axis B-mode echocardiography
• however, heart weight and total body weight are not significantly altered after 8 weeks of high-fat/high-sucrose feeding
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• mice fed a high-fat/high-sucrose diet and subjected to I/R injury show a 33.8% reduction of the infarct area in the LV at 2 days post I/R relative to control mice, as measured by triphenyltetrazolium chloride staining
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cardiovascular system
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• at 2 days post myocardial I/R injury, male mice show a 53.3% increase in isolectin B4 staining, a 56% increase in CD31 staining, and a 41.5% increase in DNAJB9 staining in heart sections from the border zone, along with a 2-fold increase in Dnajb9 mRNA levels and a 1.9-fold increase in phosphorylation of p38 mitogen-activated protein kinase (MAPK) signaling (a pathway that modulates endothelial cell migration) in the ischemic zone, indicating improved neovascularization (and recovery of LV function) after myocardial infarction
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• male mice fed a high-fat/high-sucrose diet for 8 weeks and subjected to left anterior descending (LAD) coronary artery ligation with 45-min ischemia followed by reperfusion show a 28% improvement in left ventricular (LV) ejection fraction (EF) and a 23% improvement in fractional shortening (FS) relative to control mice, as assessed by short-axis M-mode echocardiography at 2 days post I/R injury
• at 2 days post myocardial infarction, male mice also show a smaller change in EF and FS relative to baseline measurements and a 32% improvement of the LV EF by long axis B-mode echocardiography
• however, heart weight and total body weight are not significantly altered after 8 weeks of high-fat/high-sucrose feeding
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• mice fed a high-fat/high-sucrose diet and subjected to I/R injury show a 33.8% reduction of the infarct area in the LV at 2 days post I/R relative to control mice, as measured by triphenyltetrazolium chloride staining
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