Phenotypes associated with this allele

• Allele Symbol: Dync1h1^tm1.1Ics
• Allele Name: targeted mutation 1.1, Mouse Clinical Institute
• Allele ID: MGI:7616510
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dync1h1^tm1.1Ics/Dync1h1^tm1.1Ics	involves: C57BL/6 * C57BL/6N * SJL	MGI:7641494
ht2	Dync1h1^tm1.1Ics/Dync1h1^+	involves: C57BL/6 * C57BL/6N * SJL	MGI:7641497

Genotype
MGI:7641494

hm1

• Allelic Composition: Dync1h1^tm1.1Ics/Dync1h1^tm1.1Ics
• Genetic Background: involves: C57BL/6 * C57BL/6N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:334549 )

• no mice born

Genotype
MGI:7641497

ht2

• Allelic Composition: Dync1h1^tm1.1Ics/Dync1h1⁺
• Genetic Background: involves: C57BL/6 * C57BL/6N * SJL

behavior/neurological

tremors ( J:334549 )

• when walking at age P4

abnormal gait ( J:334549 )

• at ages P4 and P24

decreased locomotor activity ( J:334549 )

• at age P24

cellular

abnormal mitosis ( J:334549 )

• fewer cells entering S-phase in cerebral cortex of E14.5 embryos

• fewer mitotic cells in apical and more cells in basal cerebral cortex of E14.5 embryos

• more cells exiting cell cycle in cerebral cortex of E14.5 embryos

increased neuron apoptosis ( J:334549 )

• 7x increase in apoptotic cells in cerebral cortex of E14.5 embryos

abnormal radial glial cell morphology ( J:334549 )

• loss of radial organization in E14.5 embryos

• clustered cells in E14.5 embryos

• fewer radial glial cells in apical VZ and more in basal VZ

abnormal neuronal migration ( J:334549 )

• delayed migration in newborn cerebral cortex, with more cells in deeper layers and fewer in cortical plate

abnormal cell proliferation ( J:334549 )

• fewer proliferating cells in apical and more cells in basal cerebral cortex of E14.5 embryos

growth/size/body

decreased body size ( J:334549 )

• from birth to early death

slow postnatal weight gain ( J:334549 )

• ~50% lower body weight at age P24

mortality/aging

premature death ( J:334549 )

• no survival past 3-4 weeks

nervous system

increased neuron apoptosis ( J:334549 )

• 7x increase in apoptotic cells in cerebral cortex of E14.5 embryos

abnormal radial glial cell morphology ( J:334549 )

• loss of radial organization in E14.5 embryos

• clustered cells in E14.5 embryos

• fewer radial glial cells in apical VZ and more in basal VZ

abnormal neuronal migration ( J:334549 )

• delayed migration in newborn cerebral cortex, with more cells in deeper layers and fewer in cortical plate

abnormal cortical ventricular zone morphology ( J:334549 )

• VZ represents increased proportion of cortical wall thickness in E14.5 embryos

• fewer radial glial cells in apical VZ and more in basal VZ

• impaired VZ basal to apical interkinetic nuclear migration in E14.5 embryos

decreased brain size ( J:334549 )

• at birth

abnormal brain ventricular system morphology ( J:334549 )

• discontinuous ventricular surface in cerebral cortex of E14.5 embryos

thin cerebral cortex ( J:334549 )

• thinner cortical wall in E14.5 embryos

abnormal embryonic/fetal subventricular zone morphology ( J:334549 )

• SVZ represents decreased proportion of cortical wall thickness in somatosensory cortex of E14.5 embryos

• fewer intermediate progenitors (IPs) in somatosensory cortex SVZ of E14.5 embryos

• intermediate progenitors (IPs) distributed more towards apical part of somatosensory cortex SVZ of E14.5 embryos