Phenotypes associated with this allele

• Allele Symbol: Tmem117^tm1.1Thor
• Allele Name: targeted mutation 1.1, Bernard Thorens
• Allele ID: MGI:7616761
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tmem117^tm1.1Thor/Tmem117^tm1.1Thor	involves: C57BL/6N	MGI:7616763

Genotype
MGI:7616763

cn1

• Allelic Composition: Tmem117^tm1.1Thor/Tmem117^tm1.1Thor
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased glucagon secretion ( J:339175 )

• following viral cre-mediated recombination in the posterior pituitary, in mice treated with insulin to induce hypoglycemia

• in female mice the elevation was significant in the pro-estrus phase

• increased secretion is transient, returning to controls levels by 34 days after viral injection

increased circulating antidiuretic hormone level ( J:339175 )

• elevated copeptin (a cleavage product of vasopressin) levels following viral cre-mediated recombination in the posterior pituitary, in mice treated with insulin to induce hypoglycemia

• in female mice the elevation was significant in the pro-estrus phase

• increased secretion is transient, returning to controls levels by 34 days after viral injection

abnormal calcium level ( J:339175 )

• elevated baseline intracellular Ca2+ signaling in vasopressin neuronal terminals following viral cre-mediated recombination in the posterior pituitary

• increase in intracellular Ca2+ levels following insulin injection is higher in mice with viral cre-mediated recombination in the posterior pituitary

nervous system

decreased neuron number ( J:339175 )

• loss of vassopressin neurons following viral induced cre mediated recombination in the supraoptic nuclei

cellular

oxidative stress ( J:339175 )

• elevated ROS production in the supraoptic nuclei following viral cre-mediated recombination in the posterior pituitary

endocrine/exocrine glands

increased glucagon secretion ( J:339175 )

• following viral cre-mediated recombination in the posterior pituitary, in mice treated with insulin to induce hypoglycemia

• in female mice the elevation was significant in the pro-estrus phase

• increased secretion is transient, returning to controls levels by 34 days after viral injection