Phenotypes associated with this allele

• Allele Symbol: Mustn1^{tm1d(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1d, Wellcome Trust Sanger Institute
• Allele ID: MGI:7616867
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mustn1^tm1d(EUCOMM)Wtsi/Mustn1^tm1d(EUCOMM)Wtsi	involves: C57BL/6N * SJL	MGI:7616935

Genotype
MGI:7616935

hm1

• Allelic Composition: Mustn1^{tm1d(EUCOMM)Wtsi}/Mustn1^{tm1d(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6N * SJL
• Cell Lines: EPD0917_3_F04

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

skeletal muscle fibrosis ( J:346460 )

♀ • females, but not males, show an increase in collagen content (indicating fibrosis) 14 days after cardiotoxin-induced muscle injury compared to wild-type controls that show no remaining fibrosis

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:346460 )

N • mice show no differences in glucose tolerance and in exercise capacity at 3-4 months of age

increased susceptibility to injury ( J:346460 )

♀ • females, but not males, show an increase in collagen content (indicating fibrosis) 14 days after cardiotoxin-induced muscle injury compared to wild-type controls that show no remaining fibrosis

growth/size/body

growth/size/body region phenotype ( J:346460 )

N • mice show normal body weight and composition

cardiovascular system

cardiovascular system phenotype ( J:346460 )

N • smooth muscle cells from the descending thoracic aorta show normal proliferation and migration capacity in culture

mortality/aging

mortality/aging ( J:346460 )

N • mice are viable and are born at the expected genotype and sex ratios