Phenotypes associated with this allele

• Allele Symbol: Pakap^tm1.1Div
• Allele Name: targeted mutation 1.1, Dario Diviani
• Allele ID: MGI:7618327
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	A1cf^Tg(Myh6-cre/Esr1*)1Jmk/A1cf^+ Pakap^tm1.1Div/Pakap^tm1.1Div	involves: C57BL/6 * FVB/N	MGI:7618341

Genotype
MGI:7618341

cn1

• Allelic Composition: A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺; Pakap^tm1.1Div/Pakap^tm1.1Div
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased response of heart to induced stress ( J:345193 )

• in tamoxifen treated mice ligation of the left anterior descending coronary artery induces increased thinning of the left ventricular posterior wall and intraventricular septum and increased ventricular dilation

• in tamoxifen treated mice ligation of the left anterior descending coronary artery induces more severe cardiac dysfunction as indicated by significantly reduced fractional shortening and ejection fraction

• however, hearts of tamoxifen treated mice do not show abnormalities prior to ligation of the left anterior descending coronary artery

abnormal response to cardiac infarction ( J:345193 )

• in tamoxifen treated mice at 2 weeks post cardiac infarction left ventricular vessel density is reduced in the infarcted zone and border zone compared to controls

increased susceptibility to myocardial ischemic injury ( J:345193 )

• increased apoptosis in hearts of tamoxifen treated mice at 24 hours after ligation of the left anterior descending coronary artery

increased myocardial infarct size ( J:345193 )

• in tamoxifen treated mice increased infarct size at 2 weeks after ligation of the left anterior descending coronary artery

homeostasis/metabolism

increased response of heart to induced stress ( J:345193 )

• in tamoxifen treated mice ligation of the left anterior descending coronary artery induces increased thinning of the left ventricular posterior wall and intraventricular septum and increased ventricular dilation

• in tamoxifen treated mice ligation of the left anterior descending coronary artery induces more severe cardiac dysfunction as indicated by significantly reduced fractional shortening and ejection fraction

• however, hearts of tamoxifen treated mice do not show abnormalities prior to ligation of the left anterior descending coronary artery

abnormal response to cardiac infarction ( J:345193 )

• in tamoxifen treated mice at 2 weeks post cardiac infarction left ventricular vessel density is reduced in the infarcted zone and border zone compared to controls

increased susceptibility to myocardial ischemic injury ( J:345193 )

• increased apoptosis in hearts of tamoxifen treated mice at 24 hours after ligation of the left anterior descending coronary artery

increased myocardial infarct size ( J:345193 )

• in tamoxifen treated mice increased infarct size at 2 weeks after ligation of the left anterior descending coronary artery