Analysis Tools
vision/eye
|
• by 3 weeks of age, apoptosis in the outer nuclear layer is detected
|
|
• mitochondria within the inner segment are smaller and are mislocalized, being dispersed within the inner segment instead of being located against the plasma membrane
• rhodopsin is retained in the outer nuclear layer and inner segment in 2- and 3-week old mice, indicating that it is not normally transported to the outer segment
|
|
• loss of photoreceptors is concurrent with loss of rod outer segment proteins, including rhodopsin and transducin
|
|
• rod photoreceptors show regions of abnormal disc overgrowth or occasional dysmorphic disc membranes
|
|
• rod cells frequently have an extended periciliary ridge and in some cases, the discs in the retina grow parallel to the axoneme
|
|
• 40% loss of rods is seen at 3 weeks of age and at 6 weeks of age, rod photoreceptors are completely degenerated, with no detectable outer segment region
|
|
• rhodopsin is retained in the outer nuclear layer and inner segment in 2- and 3-week old mice, indicating that it is not normally transported to the outer segment
|
|
• 40% loss of outer nuclear layer nuclei at 3 weeks of age, indicating early rod photoreceptor degeneration
|
|
• thinning retina at 3 weeks of age
• however, the remaining outer segments appear normal
|
|
• while a-wave implicit time is not affected at 3 weeks of age, by 6 weeks of age it is reduced in both the scotopic and photopic conditions
|
|
• scotopic a-wave amplitude is diminished and photopic a-wave amplitude is reduced at 3 weeks of age, however a-wave implicit times are not affected
• at 6 weeks of age, mice show no response in the scotopic condition and the a-wave is diminished and show a decrease in photopic a-wave amplitude
|
|
• scotopic b-wave amplitude is diminished and photopic b-wave amplitude is reduced at 3 weeks of age, however b-wave implicit times are not affected
• at 6 weeks of age, mice show no response in the scotopic condition and the b-wave is diminished and show a decrease in photopic a-wave amplitude
|
nervous system
|
• microglial activity is increased and microglia are also seen in the inner segment and in the retinal ganglion cell layer, while normal location of microglia is in the plexiform layers
• retinas show an increase in GFAP-positive Muller glial processes extending up through the retina
|
|
• mitochondria within the inner segment are smaller and are mislocalized, being dispersed within the inner segment instead of being located against the plasma membrane
• rhodopsin is retained in the outer nuclear layer and inner segment in 2- and 3-week old mice, indicating that it is not normally transported to the outer segment
|
|
• loss of photoreceptors is concurrent with loss of rod outer segment proteins, including rhodopsin and transducin
|
|
• rod photoreceptors show regions of abnormal disc overgrowth or occasional dysmorphic disc membranes
|
|
• rod cells frequently have an extended periciliary ridge and in some cases, the discs in the retina grow parallel to the axoneme
|
|
• 40% loss of rods is seen at 3 weeks of age and at 6 weeks of age, rod photoreceptors are completely degenerated, with no detectable outer segment region
|
cellular
|
• by 3 weeks of age, apoptosis in the outer nuclear layer is detected
|
hematopoietic system
|
• microglial activity is increased and microglia are also seen in the inner segment and in the retinal ganglion cell layer, while normal location of microglia is in the plexiform layers
• retinas show an increase in GFAP-positive Muller glial processes extending up through the retina
|
immune system
|
• microglial activity is increased and microglia are also seen in the inner segment and in the retinal ganglion cell layer, while normal location of microglia is in the plexiform layers
• retinas show an increase in GFAP-positive Muller glial processes extending up through the retina
|
