Phenotypes associated with this allele

• Allele Symbol: Thsd4^tm1.2Lysa
• Allele Name: targeted mutation 1.2, Lynn Y Sakai
• Allele ID: MGI:7618765
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Thsd4^tm1.2Lysa/Thsd4^+	involves: C57BL/6	MGI:7618843

Genotype
MGI:7618843

ht1

• Allelic Composition: Thsd4^tm1.2Lysa/Thsd4⁺
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal aorta morphology ( J:346290 )

♂ • aortas of mice at 6 and 9 months of age show patchy presence of proteoglycans and disorganization of elastin in the extracellular matrix

♂ • however, young mice do not exhibit a defect in elastic fiber formation

abnormal aorta smooth muscle morphology ( J:346290 )

♂ • nuclei in aortic tissue exhibit a more significant degree of DNA degradation at 6 months of age

♂ • at 9 months of age, a decrease in the number of smooth muscle cell nuclei is seen, indicating loss of smooth muscle cell tissue with age

descending aorta dilation ( J:346290 )

♂

aortic arch dilation ( J:346290 )

♂

abnormal aortic sinus morphology ( J:346290 )

♂ • sinus of Valsalva dilation

dilated ascending aorta ( J:346290 )

♂

dilated aorta ( J:346290 )

♂ • mice show an increase in aortic diameter (sinus of Valsalva, ascending aorta, aortic arch, descending aorta) at 6, 8, and 12 months of age

♂ • aortic diameters increase more with time than in wild-type mice

muscle

abnormal aorta smooth muscle morphology ( J:346290 )

♂ • nuclei in aortic tissue exhibit a more significant degree of DNA degradation at 6 months of age

♂ • at 9 months of age, a decrease in the number of smooth muscle cell nuclei is seen, indicating loss of smooth muscle cell tissue with age

mortality/aging

mortality/aging ( J:346290 )

N • mice have a normal lifespan